Fluorescence-based surface magnifying chromoendoscopy and optical coherence tomography endoscope.
Fluorescence-based surface magnifying chromoendoscopy and optical coherence tomography endoscope.
复制标题
基于荧光的表面放大色素内窥镜和光学相干断层扫描内窥镜。
DOI：
10.1117/1.jbo.17.8.086003
复制
发表时间：
2012
影响因子：
3.5
通讯作者：
Barton,JenniferK
中科院分区：
文献类型：
--
作者：
Wall,RAndrew;Barton,JenniferK
A side-viewing, 2.3-mm diameter, surface magnifying chromoendoscopy-optical coherence tomography (SMC-OCT) endoscope has been designed for simultaneous, nondestructive surface fluorescence visualization and cross-sectional imaging. We apply this endoscope toin vivoexamination of the mouse colon. A 30,000 element fiber bundle is combined with single mode fibers, for SMC and OCT imaging, respectively. The distal optics consist of a gradient-index lens and spacer to provide amagnification at a working distance of 1.58 mm in air, necessary to image the sample through a 0.23-mm thick outer glass envelope, and an aluminized right-angle prism fixed to the distal end of the gradient-index lens assembly. The resultingimaging system is capable of 3.9-µm lateral and 2.3-µm axial resolution in the OCT channel, andresolution across a 0.70-mm field of view in the SMC channel. The endoscope can perform high contrast crypt visualization, molecular imaging, and cross-sectional imaging of colon microstructure.
