Determinants of Hydroxychloroquine Blood Concentration Variations in Systemic Lupus Erythematosus
Determinants of Hydroxychloroquine Blood Concentration Variations in Systemic Lupus Erythematosus
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DOI：
10.1002/art.39194
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发表时间：
2015-08-01
影响因子：
13.3
通讯作者：
Costedoat-Chalumeau, N.
中科院分区：
文献类型：
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作者：
Jallouli, M.;Galicier, L.;Costedoat-Chalumeau, N.
目标。在系统性红斑狼疮(SLE)患者中，羟基氯喹(HCQ)的血药浓度差异很大。在不同的情况下，已经发现了药代动力学/药效学关系，非常低的血药浓度是不坚持治疗的简单标志。因此，人们对血液中HCQ浓度的测量越来越感兴趣，但对影响血液HCQ浓度变异性的因素知之甚少。本研究旨在分析HCQ血药浓度的影响因素。我们对患者数据进行了回顾性分析，包括来自Plaquil狼疮系统(PLUS)研究的数据，以确定流行病学、临床和生物因素与血液HCQ浓度的关系。未依从性患者的数据(血HCQ浓度
Objective. Blood concentrations of hydroxychloroquine (HCQ) vary widely among patients with systemic lupus erythematosus (SLE). A pharmacokinetic/pharmacodynamic relationship has been found in different situations, and a very low blood concentration of HCQ is a simple marker of nonadherence to treatment. Therefore, interest in blood HCQ concentration measurement has increased, but little is known about factors that influence blood HCQ concentration variability. This study was undertaken to analyze determinants of blood HCQ concentrations.Methods. We conducted a retrospective analysis of patient data, including data from the Plaquenil Lupus Systemic (PLUS) study, to determine the association of epidemiologic, clinical, and biologic factors with blood HCQ concentrations. Data for nonadherent patients (blood HCQ concentration