Relationship between serum leptin and chronic obstructive pulmonary disease in US adults: results from the third National Health and Nutrition Examination Survey.
Relationship between serum leptin and chronic obstructive pulmonary disease in US adults: results from the third National Health and Nutrition Examination Survey.
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美国成年人血清瘦素与慢性阻塞性肺疾病的关系：第三次全国健康和营养检查调查的结果。
DOI：
10.1097/jim.0000000000000104
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发表时间：
2014
期刊：
影响因子：
--
通讯作者：
Liangpunsakul,Suthat
中科院分区：
文献类型：
--
作者：
Sueblinvong,Viranuj;Liangpunsakul,Suthat
研究背景近年来的研究表明，瘦素在呼吸道免疫反应和炎症性呼吸道疾病的发病机制中起着重要作用。目的在第三次美国国民健康与营养调查中，我们进行了一项以人群为基础的研究，以评估血清瘦素与COPD的关系。研究对象和设计我们的研究组由6415名有空腹血清瘦素的成年人组成，并进行了肺活量测定。主要结果：比较了(1)肺功能正常者和COPD患者之间以及(2)不同病情的COPD患者之间的血清瘦素水平。结果在男性参与者中，2257人为对照组，680人为COPD患者。与对照组相比，COPD患者年龄更大(62vs43岁)，吸烟率高(78%vs58%)，体重指数(BMI)低(26.3vs26.9)，血清瘦素水平高(6.6vs5.9)。对于女性参与者，2918人为对照组，560人患有COPD。COPD患者年龄较大(60岁比43岁)，BMI较低(26.9比27.7岁)。未观察到血清瘦素水平的差异。年龄、体重指数和吸烟是COPD的独立预测因素，但不是血清瘦素。不同病情的COPD患者血清瘦素水平差异无统计学意义(P>0.05)。我们的数据提供了间接证据，反对血清瘦素在人类COPD发病机制中的主要作用。
BackgroundRecent studies suggest an important role for leptin in respiratory immune responses and pathogenesis of inflammatory respiratory diseases. There has been an interest to explore whether leptin plays any role in the pathogenesis of chronic obstructive pulmonary disease (COPD).ObjectiveWe conducted a population-based study to evaluate the relationship between serum leptin and COPD in the third US National Health and Nutrition Examination Survey participants.Participants and DesignOur study group was constituted by 6415 adults who had fasting serum leptin and underwent spirometry measurement.Main Outcome MeasuresSerum leptin levels were compared (1) between subjects with normal lung function and those with COPD and (2) among COPD subjects with different severities.ResultsAmong male participants, 2257 were controls, and 680 had COPD. Compared with controls, COPD subjects were older (62 vs 43 years) and had higher prevalence of smokers (78% vs 58%), lower body mass index (BMI) (26.3 vs 26.9), and higher serum leptin levels (6.6 vs 5.9). For female participants, 2918 were controls, and 560 had COPD. Those with COPD were older (60 vs 43 years) and had lower BMI (26.9 vs 27.7). No differences in serum leptin levels were observed. The independent predictors of COPD in both sexes were age, BMI, and smoking, but not serum leptin. There were no differences in serum leptin among COPD subjects with different severities.ConclusionsWe did not find any significant difference in the levels of serum leptin in subjects with COPD. Our data provide indirect evidence against a major role for serum leptin in the pathogenesis of COPD in humans.