Age-related and sex-related changes in perfusion index in response to noxious electrical stimulation in healthy subjects
Age-related and sex-related changes in perfusion index in response to noxious electrical stimulation in healthy subjects
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DOI：
10.2147/jpr.s57140
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发表时间：
2014-01-01
影响因子：
2.7
通讯作者：
Fujino, Yuji
中科院分区：
文献类型：
--
作者：
Nishimura, Toshiki;Nakae, Aya;Fujino, Yuji
背景资料：尽管疼痛是一种主观现象，但其在人体中的客观评价很重要，因为需要疼痛评价的受试者可能由于意识降低或认知功能受损而无法描述其疼痛强度。以往的报告表明，灌注指数（PI），这是从脉搏血氧仪波形计算，在评估疼痛有一定的效用。然而，迄今为止尚未评价PI变化的年龄相关和性别相关差异以评估疼痛。因此，我们的目的是估计的效用与年龄相关的差异，在PI的变化之间的健康志愿者进行电stimulation.Methods：我们测量PI和脉搏率在70名健康志愿者暴露于逐渐增加的电刺激。研究对象分为青年男性、青年女性、老年男性和老年女性四组。当受试者达到其疼痛耐受阈值时，停止刺激。计算电刺激前后10秒的平均PI和脉率，并在四组之间进行比较。结果：青年男性疼痛刺激后PI明显降低（P
Background: Even though pain is a subjective phenomenon, its objective evaluation in humans is important because subjects requiring pain evaluation may be unable to describe their pain intensity because of decreased awareness or impaired cognitive function. Previous reports indicate that the perfusion index (PI), which is calculated from pulse oximeter waveforms, has some utility in assessing pain. However, age-associated and sex-associated differences in change of PI have hitherto not been evaluated for assessment of pain. Therefore, we aimed to estimate the utility of age-related differences in PI change among healthy volunteers subjected to electrical stimulation.Methods: We measured PI and pulse rate in 70 healthy volunteers exposed to gradually increasing electrical stimulation. The subjects were classified into four groups, ie, young men, young women, aged men, and aged women. Stimulation was stopped when subjects reached their pain tolerance threshold. The average PI and pulse rate were calculated 10 seconds before and after electrical stimulation and compared across the four groups. Changes in PI and pulse rate were analyzed using the paired t-test.Results: The PI was significantly decreased in response to pain stimulation in young men (P