Advanced drug delivery systems of curcumin for cancer chemoprevention.
Advanced drug delivery systems of curcumin for cancer chemoprevention.
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DOI：
10.1158/1940-6207.capr-10-0006
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发表时间：
2011-08
期刊：
影响因子：
--
通讯作者：
Gupta RC
中科院分区：
文献类型：
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作者：
Bansal SS;Goel M;Aqil F;Vadhanam MV;Gupta RC
自古以来，化学预防剂就被用来治疗/预防多种疾病，包括癌症。在各种细胞培养和一些动物研究中发现它们引起一系列有效的反应，包括抗炎、抗氧化、抗增殖、抗癌和抗血管生成活性。过去40年的研究表明，化学预防剂会影响参与调节细胞中炎症和致癌反应的各种分子途径的许多蛋白质。各种酶、转录因子、受体和粘附蛋白也受到化学预防剂的影响。尽管这些天然化合物在细胞培养研究中显示出显著的功效，但它们在各种临床研究中引起的功效有限。它们引入临床环境的主要障碍是它们的溶解度差、代谢快或两者的组合，最终导致口服给药时生物利用度差。因此，为了规避这些限制，并使他们更容易过渡到诊所，应探索替代策略。药物递送系统如纳米颗粒、脂质体、微乳液和聚合物可植入装置正在成为可行的替代方案之一，其已被证明可将治疗浓度的各种有效化学预防剂如姜黄素、鞣花酸、绿色茶多酚和白藜芦醇递送到体循环中。在这篇综述文章中，我们试图提供一个全面的前景，这些交付的方法，使用姜黄素作为模型代理，并讨论了未来的战略，使这些高度有效的化学预防引入到医生的医疗设备。
From ancient times, chemopreventive agents have been used to treat/prevent several diseases, including cancer. They are found to elicit a spectrum of potent responses including anti-inflammatory, anti-oxidant, anti-proliferative, anti-carcinogenic, and anti-angiogenic activity in various cell culture and some animal studies. Research over the past four decades has shown that chemopreventives affect a number of proteins involved in various molecular pathways that regulate inflammatory and carcinogenic responses in a cell. Various enzymes, transcription factors, receptors, and adhesion proteins are also affected by chemopreventives. Although, these natural compounds have shown significant efficacy in cell-culture studies, they elicited limited efficacy in various clinical studies. Their introduction into the clinical setting is hindered largely by their poor solubility, rapid metabolism, or a combination of both, ultimately resulting in poor bioavailability upon oral administration. Therefore, to circumvent these limitations and to ease their transition to clinics, alternate strategies should be explored. Drug delivery systems such as nanoparticles, liposomes, microemulsions, and polymeric implantable devices are emerging as one of the viable alternatives that have been demonstrated to deliver therapeutic concentrations of various potent chemopreventives such as curcumin, ellagic acid, green tea polyphenols, and resveratrol into the systemic circulation. In this review article, we have attempted to provide a comprehensive outlook for these delivery approaches, using curcumin as a model agent, and discussed future strategies to enable the introduction of these highly potent chemopreventives into a physician’s armamentarium.