REPLICATION OF AVIAN INFLUENZA-VIRUSES IN HUMANS
REPLICATION OF AVIAN INFLUENZA-VIRUSES IN HUMANS
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DOI：
10.1007/bf01314321
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发表时间：
1991-01-01
影响因子：
2.7
通讯作者：
WEBSTER, RG
中科院分区：
文献类型：
--
作者：
BEARE, AS;WEBSTER, RG
接种了目前在人类中流行的亚型（H1N1和H3N2）禽流感病毒的志愿者基本不会感染。然而，在接种了禽流感亚型H4N8、H6N1和H10N7的40名志愿者中，有11人排出了病毒并出现了轻微的临床症状：他们没有产生可检测到的抗体反应。这可能是因为病毒增殖有限，不足以刺激可检测到的初次免疫反应。禽流感病毒包含血凝素（HA）1 - 14亚型，人类尚未发现的HA基因有可能通过禽流感病毒和流行的人类流感病毒之间的重配进入人类流感病毒基因库。
Volunteers inoculated with avian influenza viruses belonging to subtypes currently circulating in humans (H1N1 and H3N2) were largely refractory to infection. However 11 out of 40 volunteers inoculated with the avian subtypes, H4N8, H6N1, and H10N7, shed virus and had mild clinical symptoms: they did not produce a detectable antibody response. This was presumably because virus multiplication was limited and insufficient to stimulate a detectable primary immune response. Avian influenza viruses comprise hemagglutinin (HA) subtypes 1-14 and it is possible that HA genes not so far seen in humans could enter the human influenza virus gene pool through reassortment between avian and circulating human viruses.