Dengue viruses in Brazil, 1986-2006
Dengue viruses in Brazil, 1986-2006
复制标题
DOI：
10.1590/s1020-49892007001000009
复制
发表时间：
2007-11-01
期刊：
影响因子：
--
通讯作者：
Schatzmayr, Hermann Gonçalves
中科院分区：
文献类型：
--
作者：
Nogueira, Rita Maria Ribeiro;Araújo, Josélio Maria Galvão de;Schatzmayr, Hermann Gonçalves
1981年至2006年间，巴西共报告了4 243 049例登革热病例，其中5 817例登革出血热/登革热休克综合征（DHF/DSS）病例，共有338例死亡病例。尽管巴西所有地区都受到影响，但东北部和东南部地区的通报数量最多。 1981年和1982年，DENV-1和DENV-4首次在巴西亚马逊地区分离出来。1986年和1990年里约热内卢州分别爆发DENV-1和DENV-2后，该疾病成为全国性的公共卫生问题。 2000 年，同样在里约热内卢州引入 DENV-3，导致了严重的登革热疫情，报告了 288 245 例登革热病例，其中 91 人死亡。 2002 年流行期间分型的病毒株显示，DENV-3 已取代其他登革热病毒血清型并进入新的地区，这一发现值得进行更密切的评估。在该国至少三个地区的登革热患者中观察到了不寻常的临床症状，包括中枢神经系统受累。
A total of 4 243 049 dengue cases have been reported in Brazil between 1981 and 2006, including 5 817 cases of dengue hemorrhagic fever/dengue shock syndrome (DHF/DSS) and a total of 338 fatal cases. Although all Brazilian regions have been affected, the Northeast and Southeast regions have registered the highest number of notifications. DENV-1 and DENV-4 were isolated for the first time in the Amazon region of Brazil in 1981 and 1982. The disease became a nationwide public health problem following outbreaks of DENV-1 and DENV-2 in the state of Rio de Janeiro in 1986 and 1990, respectively. The introduction of DENV-3 in 2000, also in the state of Rio de Janeiro, led to a severe epidemic with 288 245 reported dengue cases, including 91 deaths. Virus strains that were typed during the 2002 epidemic show that DENV-3 has displaced other dengue virus serotypes and entered new areas, a finding that warrants closer evaluation.Unusual clinical symptoms, including central nervous system involvement, have been observed in dengue patients in at least three regions of the country.