Synthesis and characterization of PEG dimethacrylates and their hydrogels
Synthesis and characterization of PEG dimethacrylates and their hydrogels
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DOI：
10.1021/bm0498777
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发表时间：
2004-07-01
影响因子：
6.2
通讯作者：
Washburn, NR
中科院分区：
文献类型：
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作者：
Lin-Gibson, S;Bencherif, S;Washburn, NR
描述了光聚合和生物相容性聚乙二醇二甲基丙烯酸酯 (PEGDM) 和聚乙二醇氨基甲酸酯二甲基丙烯酸酯 (IPEGUDM) 的简便合成和详细表征。不同分子量（M-n = 1000 至 8000 g/mol）的聚乙二醇与甲基丙烯酸酐或甲基丙烯酸 2-异氰酸乙酯反应，分别形成 PEGDM 和 PEGUDM。 PEGDM 还通过微波辅助途径制备，以在无溶剂条件下实现快速反应转化。 H-1 NMR 和 MALDI-TOF MS 的联合分析证实了高纯度和窄质量分布 (PD < 1.02) 的预聚物的形成。将 PEGDM 和 PEGUDM（质量分数 10% 和 20%）的水溶液进行光聚合以产生水凝胶。接种在水凝胶中的牛软骨细胞用于评估生物相容性。初步的神学和单轴压缩测量显示出不同的机械响应，生物相容性研究表明两周后细胞在两种类型的水凝胶中完全存活。
Facile synthesis and detailed characterization of photopolymerizable and biocompatible poly(ethylene glycol) dimethacrylates (PEGDM) and poly(ethylene glycol) urethane-dimethacrylates (IPEGUDM) are described. Poly(ethylene glycol)s of various molecular masses (M-n = 1000 to 8000 g/mol) were reacted with methacrylic anhydride or with 2-isocyanatoethyl methacrylate to form PEGDMs and PEGUDMs, respectively. PEGDMs were also prepared by a microwave-assisted route to achieve fast reaction conversions under solvent free conditions. Combined analyses of H-1 NMR and MALDI-TOF MS confirmed the formation of prepolymers of high purity and narrow mass distribution (PD < 1.02). Aqueous solutions of the PEGDMs and PEGUDMs (10% and 20% by mass fraction) were photopolymerized to yield hydrogels. Bovine chondrocytes, seeded in the hydrogels, were used to assess the biocompatibility. Preliminary theology and uniaxial compression measurements showed varied mechanical response, and biocompatibility studies showed that cells are completely viable in both types of hydrogels after two weeks.