The Gut Microbiota of Wild Mice.
The Gut Microbiota of Wild Mice.
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DOI：
10.1371/journal.pone.0134643
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发表时间：
2015
期刊：
影响因子：
3.7
通讯作者：
Viney M
中科院分区：
文献类型：
--
作者：
Weldon L;Abolins S;Lenzi L;Bourne C;Riley EM;Viney M
肠道微生物区系对宿主的生物学有深远的影响。微生物区系的组成是动态的，受到宿主遗传和许多环境影响的影响。对实验室小鼠的肠道微生物区系进行了广泛的研究，发现了微生物区系可能具有的许多影响。这项工作还表明，不同研究机构的环境可以影响小鼠的微生物区系。对野生小鼠的微生物区系的研究相对有限，但这表明它通常不同于实验室小鼠的微生物区系(在实验室中维持野生捕获的小鼠可以很快改变微生物区系)。野生老鼠的微生物区系也存在个体间的差异，这主要是由地理位置所解释的。在这项研究中，我们描述了英国三个地点野生捕获的家鼠肠道(盲肠和直肠)微生物区系的特征，并调查了微生物区系如何根据宿主位置和宿主特征而变化。我们发现，这些小鼠的微生物区系与其他野生小鼠描述的微生物区系大体一致。与其他个体的微生物区系相比，小鼠的直肠和盲肠微生物区系通常彼此更相似。我们发现，来自不同样本地点的小鼠之间微生物群落的多样性存在显著差异。微生物区系多样性与体重、年龄、体重指数、血清瘦素浓度、病毒、线虫和螨类感染显著相关。
The gut microbiota profoundly affects the biology of its host. The composition of the microbiota is dynamic and is affected by both host genetic and many environmental effects. The gut microbiota of laboratory mice has been studied extensively, which has uncovered many of the effects that the microbiota can have. This work has also shown that the environments of different research institutions can affect the mouse microbiota. There has been relatively limited study of the microbiota of wild mice, but this has shown that it typically differs from that of laboratory mice (and that maintaining wild caught mice in the laboratory can quite quickly alter the microbiota). There is also inter-individual variation in the microbiota of wild mice, with this principally explained by geographical location. In this study we have characterised the gut (both the caecum and rectum) microbiota of wild caught Mus musculus domesticus at three UK sites and have investigated how the microbiota varies depending on host location and host characteristics. We find that the microbiota of these mice are generally consistent with those described from other wild mice. The rectal and caecal microbiotas of individual mice are generally more similar to each other, than they are to the microbiota of other individuals. We found significant differences in the diversity of the microbiotas among mice from different sample sites. There were significant correlations of microbiota diversity and body weight, a measure of age, body-mass index, serum concentration of leptin, and virus, nematode and mite infection.