JBP485 promotes corneal epithelial wound healing.
JBP485 promotes corneal epithelial wound healing.
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DOI：
10.1038/srep14776
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发表时间：
2015-10-01
影响因子：
4.6
通讯作者：
Kinoshita S
中科院分区：
文献类型：
--
作者：
Nagata M;Nakamura T;Hata Y;Yamaguchi S;Kaku T;Kinoshita S
适当的伤口愈合对于维持角膜的完整性和透明度至关重要。角膜上皮损伤是最常见的眼部疾病之一。由于临床选择有限，因此需要进一步的新治疗方法来改善此类疾病的临床结局。在本研究中，发现胎盘提取物衍生的二肽（JBP 485）显著增加角膜上皮细胞（CEC）的增殖和迁移。此外，JBP 485在体内加速角膜上皮伤口愈合而没有炎症和新血管形成，并且被发现对治疗角膜损伤有效。这些数据表明，JBP 485有效地激活CEC的活力，并具有作为各种角膜上皮疾病的新治疗的潜力。
Proper wound healing is vital for maintenance of corneal integrity and transparency. Corneal epithelial damage is one of the most frequently observed ocular disorders. Because clinical options are limited, further novel treatments are needed to improve clinical outcomes for this type of disease. In the present study, it was found that placental extract-derived dipeptide (JBP485) significantly increased the proliferation and migration of corneal epithelial cells (CECs). Moreover, JBP485 accelerated corneal epithelial wound healing in vivo without inflammation and neovascularization and was found to be effective for the treatment of corneal damage. These data indicate that JBP485 efficiently activates the viability of CECs and has potential as a novel treatment for various kinds of corneal epithelial disease.