Targeting subchondral bone mesenchymal stem cell activities for intrinsic joint repair in osteoarthritis.
Targeting subchondral bone mesenchymal stem cell activities for intrinsic joint repair in osteoarthritis.
复制标题
DOI：
10.4155/fsoa-2017-0055
复制
发表时间：
2017-11
影响因子：
2.5
通讯作者：
Jones E
中科院分区：
文献类型：
--
作者：
Ilas DC;Churchman SM;McGonagle D;Jones E
骨关节炎（OA）是一种常见的与年龄相关的疾病，其病理生理机制复杂。其特征在于广泛的组织损伤和整个关节的最终生物力学失效。然而，在OA影响的骨软骨组织中，组织适应和尝试修复反应的迹象是明显的。在这篇综述文章中强调的是骨驻留间充质干细胞（MSC）在这些骨重建反应中的作用，并建议在OA软骨下骨中靶向MSC活动可能代表OA内在关节再生的新方法。这些疗法的发展将需要更好地了解与OA组织损伤相关的MSC增殖、迁移和分化模式，并进一步阐明疾病进展期间这些MSC中的分子信号传导事件。骨关节炎（OA）是一种关节疾病，其中软骨、底层骨和其他关节组织受到影响。最近的证据表明，在这些OA组织中尝试修复反应挑战了OA作为退行性疾病的传统观点。组织再生的迹象在位于受损软骨正下方的骨中特别明显，在那里观察到干细胞活性增加。靶向这些干细胞可能代表了OA内在关节再生的新方法。为了开发这些新疗法，需要更好地了解正常和OA关节组织中的干细胞功能。
Osteoarthritis (OA) is a common age-related disease with complex pathophysiology. It is characterized by wide-ranging tissue damage and ultimate biomechanical failure of the whole joint. However, signs of tissue adaptation and attempted repair responses are evident in OA-affected osteochondral tissues. Highlighted in this review article is the role of bone-resident mesenchymal stem cells (MSCs) in these bone remodeling responses, and a proposal that targeting MSC activities in OA subchondral bone could represent a novel approach for intrinsic joint regeneration in OA. The development of these therapies will require better understanding of MSC proliferation, migration and differentiation patterns in relation to OA tissue damage and further clarification of the molecular signaling events in these MSCs during disease progression. Osteoarthritis (OA) is a joint disorder, in which the cartilage, the underlying bone and other joint tissues are affected. Recent evidence demonstrating attempted repair responses in these OA tissues challenges the traditional view of OA as a degenerative disorder. Signs of tissue regeneration are particularly evident in the bone located directly underneath the damaged cartilage, where increased stem cell activity has been observed. Targeting these stem cells could represent a novel approach for intrinsic joint regeneration in OA. To progress with developing these novel therapies, a better understanding of stem cell function in normal and OA joint tissues is needed.