ROLE OF ATP-SENSITIVE K+ CHANNEL ON ECG ST SEGMENT ELEVATION DURING A BOUT OF MYOCARDIAL-ISCHEMIA - A STUDY ON EPICARDIAL MAPPING IN DOGS
ROLE OF ATP-SENSITIVE K+ CHANNEL ON ECG ST SEGMENT ELEVATION DURING A BOUT OF MYOCARDIAL-ISCHEMIA - A STUDY ON EPICARDIAL MAPPING IN DOGS
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DOI：
10.1161/01.cir.88.4.1845
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发表时间：
1993-10-01
期刊：
影响因子：
37.8
通讯作者：
TOMOIKE, H
中科院分区：
文献类型：
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作者：
KUBOTA, I;YAMAKI, M;TOMOIKE, H
背景。atp敏感的K+通道在心肌缺血时被激活。然而，atp敏感的K+电流在缺血时ECG ST改变中的作用尚不清楚。方法与结果。在8只麻醉开胸犬的左冠状动脉前降支（LAD）上插管并灌注颈动脉的动脉血。一个由60个单极电极组成的阵列安装在袜子上，用来记录整个心脏的心外膜电图。Pinacidil（10杯）。公斤。将atp敏感的K+通道开启剂min-1)输注于旁路管内2分钟，记录输注前后的心电图。在空间上观察到lad灌注区ST段的升高和QRST面积的增加。在ST段抬高幅度最大的电极上，动作电位持续时间指标激活恢复间隔从202+/-9毫秒缩短至111+/-18毫秒(P
Background. ATP-sensitive K+ channels are activated when the myocardium becomes ischemic. However, the role of the ATP-sensitive K+ current in the emergence of ECG ST changes during ischemia remained unclarified.Methods and Results. The left anterior descending coronary artery (LAD) was cannulated and perfused with arterial blood from the carotid artery through a bypass tube in 8 anesthetized, open-chest dogs. An array of 60 unipolar electrodes mounted on a sock was used to record epicardial electrograms of the whole heart. Pinacidil (10 mug . kg-1 . min-1), an ATP-sensitive K+ channel opener, was infused into the bypass tube for 2 minutes, and the electrograms were recorded before and after the infusion. The elevation of the ST segment and the increase of QRST area were observed spatially over the LAD-perfused region. At the electrode showing the largest ST segment elevation, the activation recovery interval, an index of action potential duration, was shortened from 202+/-9 to 111+/-18 milliseconds (P