Development of a Musculoskeletal Model of Hyolaryngeal Elements for Understanding Pharyngeal Swallowing Mechanics
Development of a Musculoskeletal Model of Hyolaryngeal Elements for Understanding Pharyngeal Swallowing Mechanics
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DOI：
10.3390/app10186276
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发表时间：
2020-09-01
影响因子：
2.7
通讯作者：
Koike, Takuji
中科院分区：
文献类型：
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作者：
Hashimoto, Takuya;Urabe, Mariko;Koike, Takuji
这项研究的潜在应用是提供一个关键工具，帮助研究人员和临床医生了解神经、肌肉和骨骼系统是如何参与吞咽的。这将有助于临床决策过程中治疗与神经肌肉疾病相关的吞咽困难。详细了解人类吞咽过程中的肌肉活动将为深入了解吞咽背后复杂的神经肌肉协调提供洞察力。本研究的目的是引入肌肉骨骼分析来研究吞咽过程中的肌肉活动，因为传统的肌电测量方法在研究全面的肌肉活动模式方面存在局限性。根据一名健康志愿者的CT数据制作的骨骼模型，建立了一种新的吞咽肌肉骨骼模型。采用静态优化逆动力学计算方法预测咽部吞咽过程中的个体肌力，其中舌骨和甲状软骨的典型轨迹来自志愿者的视频透视(VF)数据。研究结果表明，咽部吞咽中的个别肌肉与舌骨和甲状软骨的运动有关。肌肉活动的预测序列与先前研究中细丝肌电测量的显著特征显示出定性的一致。如果通过成像和肌电研究进一步验证这种方法，就可以更广泛地研究吞咽过程中神经肌肉的协调。该方法为理解吞咽的生理机制提供了一条途径，并可用于评估吞咽困难的康复效果。
Featured ApplicationThe potential application of this study is to provide a key tool to help researchers and clinicians understand how neuro, muscular, and skeletal systems are involved in swallowing. It would contribute to the clinical decision-making process in treating dysphagia associated with neuromuscular disease.A detailed understanding of muscle activity in human swallowing would provide insights into the complex neuromuscular coordination underlying swallowing. The purpose of this study was to introduce musculoskeletal analysis to investigate muscle activities involved in swallowing as there are limitations on studying comprehensive muscle activation patterns by conventional methods such as electromyography (EMG) measurement. A musculoskeletal model of swallowing was newly developed based on the skeletal model made from CT data of a healthy volunteer. Individual muscle forces were predicted in pharyngeal swallowing by inverse dynamics' computations with static optimization, in which the typical trajectories of the hyoid bone and thyroid cartilage analyzed from videofluoroscopic (VF) data of the volunteer were used. The results identified the contribution of individual muscles in pharyngeal swallowing in relation to the movements of the hyoid bone and thyroid cartilage. The predicted sequence of muscle activity showed a qualitative agreement with salient features in previous studies with fine wire EMG measurements. This method, if validated further by imaging and EMG studies, enables studying a broader range of neuromuscular coordination in swallowing. The proposed method offers an avenue to understanding the physiological mechanisms of swallowing and could become useful to evaluate rehabilitation effects on dysphagia.