Electroacupuncture prevents cognitive deficits in pilocarpine-epileptic rats
Electroacupuncture prevents cognitive deficits in pilocarpine-epileptic rats
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DOI：
10.1016/j.neulet.2005.04.079
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发表时间：
2005-08-26
影响因子：
2.5
通讯作者：
Mello, LE
中科院分区：
文献类型：
--
作者：
dos Santos, JG;Tabosa, A;Mello, LE
在这里，我们研究了电针对匹鲁卡品癫痫大鼠模型认知功能障碍的影响。在位于背部和头部中线的穴位[HD]：Gv-20（百会穴）、Gv-14（大椎穴）、Gv-2（腰俞穴）和M-HN-3（阴汤穴）;或位于四肢的穴位[LB]：St-36（足三里）和Sp-6（三阴交）提供针刺刺激。在高架T-迷宫测试中，电针HD和LB穴位产生的收购和保留参数的改善。抑制性回避试验中的保留仅见于短期保留，且仅见于HD刺激的动物。在组织学上，发现电针HD穴位取消背海马，杏仁核基底外侧核，黑质和嗅周皮质的组织收缩，而LB穴位刺激防止除背海马以外的所有上述结构的组织收缩。给药对氯苯丙氨酸，一种肾上腺素能受体，消除了这些动物的行为和部分组织学变化。我们的结论是，电针HD和LB穴位防止萎缩的边缘系统的一些结构，并改善认知功能障碍的匹罗卡品癫痫大鼠，这种效果是依赖于肾上腺素能系统。(c)2005爱思唯尔爱尔兰有限公司保留所有权利。
Here we investigated the effects of electroacupuncture over the cognitive deficits in the pilocarpine model of epilepsy in rats. Acupuncture stimulation was provided at acupoints located in either the midline of the back and of the head [HD]: Gv-20 (Baihui), Gv-14 (Dazhui), Gv-2 (Yaoshu) and M-HN-3 (Yin Tang); or acupoints located in the limbs [LB]: St-36 (Zusanli) and Sp-6 (Sanyinjiao). In the elevated T-maze test, electroacupuncture at HD and LB acupoints produced an improvement in the acquisition and retention parameters. Retention in the inhibitory avoidance test was seen only in short-term retention and only for animals stimulated at HD. At histology it was found that electroacupuncture at HD acupoints abolished tissue shrinkage in dorsal hippocampus, basolateral nucleus of the amygdala, substantia nigra and perirhinal cortex, whereas stimulation of LB acupoints prevented tissue shrinkage in all of the above structures except dorsal hippocampus. Administration of p-chlorophenylalanine, a serotonergic releaser, abolished both behavioral and part of the histological changes in these animals. We conclude that electroacupuncture at HD and LB acupoints prevents atrophy of some limbic structures and improves cognitive deficits in pilocarpine-epileptic rats and that this effect is dependent on the serotonergic system. (c) 2005 Elsevier Ireland Ltd. All rights reserved.