ACTIVATION OF THE COMPLEMENT-SYSTEM IN SYSTEMIC-SCLEROSIS - RELATIONSHIP TO CLINICAL SEVERITY
ACTIVATION OF THE COMPLEMENT-SYSTEM IN SYSTEMIC-SCLEROSIS - RELATIONSHIP TO CLINICAL SEVERITY
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DOI：
10.1002/anr.1780321011
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发表时间：
1989-10-01
影响因子：
--
通讯作者：
BLACK, CM
中科院分区：
文献类型：
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作者：
SENALDI, G;LUPOLI, S;BLACK, CM
使用新开发的技术，我们调查了补体途径和他们的激活程度与系统性硬化症（SSc）患者的弥漫性皮肤和有限的皮肤类型。在SSc患者和匹配的对照受试者中测量片段C3d、C4d和Ba的血浆水平。SSc患者的所有片段和比率均高于对照组（P < 0.05），表明SSc中发生补体激活。弥漫性皮肤型SSc组C3 d、C3 d：C3、Ba、Ba：B因子水平均高于局限性SSc组（P < 0.01）。弥漫性皮肤型SSc患者的所有片段和比率均高于对照组（P < 0.01）。局限性皮肤SSc组C3d、C3d：C3、C4d和C4d：C4水平也高于对照组（P < 0.05）。这些结果表明，补体激活发生在SSc患者中，并且它反映了临床严重程度。因此，补体激活可能在SSc中具有致病作用，并且其测量可能被证明在监测疾病中是有用的。
Using newly developed techniques, we investigated the complement pathways and the extent of their activation in patients with systemic sclerosis (SSc) of both the diffuse cutaneous and limited cutaneous types. Plasma levels of the fragments C3d, C4d, and Ba were measured in patients with SSc and in matched control subjects. All fragments and ratios were higher in SSc patients than in controls (P < 0.05), demonstrating that complement activation occurs in SSc. Levels of C3d, C3d:C3, Ba, and Ba:factor B were higher in patients with diffuse cutaneous SSc than in those with limited SSc (P < 0.01). All fragments and ratios were higher in diffuse cutaneous SSc patients than in controls (P < 0.01). C3d, C3d:C3, C4d, and C4d:C4 levels were also higher in patients with limited cutaneous SSc than in controls (P < 0.05). These results show that complement activation occurs in SSc patients an that it reflects clinical severity. Complement activation may therefore have a pathogenetic role in SSc, and its measurement may prove useful in monitoring the disease.