Consequences of an Adolescent Onset and Persistent Course of Alcohol Dependence in Men: Adolescent Risk Factors and Adult Outcomes
Consequences of an Adolescent Onset and Persistent Course of Alcohol Dependence in Men: Adolescent Risk Factors and Adult Outcomes
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DOI：
10.1111/j.1530-0277.2010.01154.x
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发表时间：
2010-05-01
影响因子：
3.2
通讯作者：
McGue, Matt
中科院分区：
文献类型：
--
作者：
Hicks, Brian M.;Iacono, William G.;McGue, Matt
背景：虽然有大量关于酒精使用障碍相关性的文献(AUD；方法：以530名男性为研究对象，采用纵向的社区抽样方法，研究青春期AUD起病(17岁以上)和AUD持续病程(29岁以上)对青少年和成人功能的影响，包括药物使用、反社会行为、心理健康问题、整体心理社会功能、环境风险和保护因素，以及同伴和恋爱关系、婚姻、教育和职业成就等社会结果。结果：青春期AUD(n=57)与青春期多个心理社会功能领域的严重缺陷有关。青春期的行为去抑制措施是持续AUD病程的强烈预测因素(n=93)。在青春期发作的男性中，近40%的人能够在29岁前戒烟，这一点与从未经历过AUD的男性在成人功能方面相似，但并不完全相同。青春期发病且持续AUD的男性表现出最严重的功能缺陷。结论：结果强调了检查发育过程对了解AUD病因的重要性。我们的发现是乐观的，因为停止使用AUD的人能够实现高水平的心理社会功能。我们的发现表明，未来关于AUD持续到成年的研究应该侧重于行为去抑制和社会环境变量的贡献，包括同伴关系和浪漫关系。
Background:While there is an extensive literature on the correlates of alcohol use disorders (AUD; alcohol abuse and dependence), there are relatively few prospective studies of representative birth cohorts that have examined the unique effects of an adolescent onset and persistent course of AUD on a wide range of psychosocial variables.Methods:A longitudinal, community-based sample of 530 men was used to examine the impact of an adolescent onset (AUD+ at age 17) and persistent course (AUD+ at age 29) of AUD on adolescent and adult functioning including substance use, antisocial behavior, mental health problems, overall psychosocial functioning, environmental risk and protective factors, and social outcomes such as peer and romantic relationships, marriage, educational and occupational attainment, and parenthood.Results:An adolescent onset of AUD (n = 57) was associated with severe deficits across multiple domains of psychosocial functioning in adolescence. Measures of behavioral disinhibition in adolescence were strong predictors of a persistent course of AUD (n = 93). Nearly 40% of men with an adolescent onset were able to desist by age 29, and were similar, but not identical to men who never experienced an AUD in terms of adult functioning. Men with an adolescent onset and persistent course of AUD exhibited the most severe deficits in functioning.Conclusion:Results emphasize the importance of examining developmental course to understand the etiology of AUD. Our findings are optimistic in that individuals who desist from AUD are able to achieve high levels of psychosocial functioning. Our findings suggest that future research on the persistence of AUD into adulthood should focus on the contributions of behavioral disinhibition and social environment variables including peer and romantic relationships.