Copper-Catalyzed Enantioselective Allyl-Allyl Cross-Coupling
Copper-Catalyzed Enantioselective Allyl-Allyl Cross-Coupling
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DOI：
10.1021/ja312487r
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发表时间：
2013-02-13
影响因子：
15
通讯作者：
Feringa, Ben L.
中科院分区：
文献类型：
--
作者：
Hornillos, Valentin;Perez, Manuel;Feringa, Ben L.
报道了一种基于亚磷酰胺的Cu（I）催化体系，该体系允许具有高对映选择性的不对称烯丙基-烯丙基交叉偶联。这种转化耐受各种各样的官能化底物。这种新的反应的多功能性说明在催化不对称合成的Martinelline生物碱色烯衍生物的核心。
A Cu(I)-phosphoramidite-based catalytic system that allows asymmetric allyl-allyl cross-coupling with high enantioselectivity is reported. This transformation tolerates a large variety of functionalized substrates. The versatility of this new reaction is illustrated in the catalytic asymmetric synthesis of the Martinelline alkaloids chromene derivative core.