Levels of IL‐12 in the sera of patients with systemic lupus erythematosus (SLE)—relation to Th1‐ and Th2‐derived cytokines
Levels of IL‐12 in the sera of patients with systemic lupus erythematosus (SLE)—relation to Th1‐ and Th2‐derived cytokines
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DOI：
10.1046/j.1365-2249.1999.00862.x
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发表时间：
1999-04
影响因子：
4.6
通讯作者：
Y. Tokano;S. Morimoto;H. Kaneko;H. Amano;K. Nozawa;Y. Takasaki;H. Hashimoto
中科院分区：
文献类型：
--
作者：
Y. Tokano;S. Morimoto;H. Kaneko;H. Amano;K. Nozawa;Y. Takasaki;H. Hashimoto
IL-12 是一种诱导 Th1 衍生细胞因子（干扰素-γ (IFN-γ) 和 IL-2）的细胞因子。 IL-12 在人类自身免疫中的意义尚不清楚，并且 IL-12 在 SLE 中的血清水平尚未明确确定。因此，我们采用夹心 ELISA 检测了 39 名活动性 SLE 患者的 IL-12 水平。患者的IL-12水平显着高于正常人。 IL-12水平高的患者IFN-γ水平也高，而IL-13水平显着低于IL-12水平正常的患者。肺部受累患者的 IL-12 水平较高，类固醇治疗降低了三名患者的 IL-12 水平。在对 7 名患者进行的回顾性研究中，在疾病发作之前发现了 IL-12 和 IL-13 的各种变化。因此，在 SLE 患者中，IL-12 水平升高，这种升高与某些器官受累的 Th1 或 Th2 衍生细胞因子的变化有关。
IL‐12 is a cytokine that induces Th1‐derived cytokines (interferon‐gamma (IFN‐γ) and IL‐2). The significance of IL‐12 in human autoimmunity is no clear, and the serum levels of IL‐12 in SLE are not clearly established. Therefore, we examined the levels of IL‐12 in 39 patients with active SLE, with sandwich ELISA. The levels of IL‐12 in patients were significantly higher than in normal subjects. Patients with high levels of IL‐12 also had high levels of IFN‐γ, while their levels of IL‐13 were significantly lower than in patients with normal levels of IL‐12. Patients with pulmonary involvement had high levels of IL‐12, and steroid therapy decreased the IL‐12 level in three patients. In a retrospective study of seven patients, various changes of IL‐12 and IL‐13 were recognized before disease flare. Thus, in SLE patients, the level of IL‐12 was increased and this increase was related to the change of Th1‐ or Th2‐derived cytokines with some organ involvement.