Isolation and structural elucidation of the crellastatins I-M:: Cytotoxic bis-steroid derivatives from the Vanuatu marine sponge Crella sp.
Isolation and structural elucidation of the crellastatins I-M:: Cytotoxic bis-steroid derivatives from the Vanuatu marine sponge Crella sp.
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DOI：
10.1016/s0040-4020(99)00858-3
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发表时间：
1999-11-26
期刊：
影响因子：
2.1
通讯作者：
D'Auria, MV
中科院分区：
文献类型：
--
作者：
Giannini, C;Zampella, A;D'Auria, MV
Continued investigation of cytotoxic extracts of the marine sponge Crella sp. has resulted in the discovery of crellastatins I-M (2-6). Their structures were determined by interpretation of their NMR spectroscopic and FABMS data. These new his-steroid derivatives exhibited cytotoxic activity against NSCLC cell lines with IC50 values in the range of 1-8 mu g/ml. (C) 1999 Elsevier Science Ltd. All rights reserved.
