Immune response to the filaria Litomosoides sigmodontis in susceptible and resistant mice
Immune response to the filaria Litomosoides sigmodontis in susceptible and resistant mice
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DOI：
10.1046/j.1365-3024.1997.d01-209.x
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发表时间：
1997-06-01
影响因子：
2.2
通讯作者：
Petit, G
中科院分区：
文献类型：
--
作者：
Marechal, P;LeGoff, L;Petit, G
本文比较了敏感BALB/c小鼠慢性感染和未感染乙状结肠吸虫的免疫应答，以及B10.D2小鼠未感染乙状结肠吸虫的免疫应答。两种品系小鼠脾细胞的早期抗原特异性反应均较弱。然而，到感染后第58天，在BALB/c小鼠中观察到强烈的Th 2应答，如通过IL-4、IL-5和IL-10的产生所确定的，但在B10.D2小鼠中未观察到。B10.D2小鼠的抗体应答似乎比BALB/c小鼠更早出现，并且这些差异识别15 kD和80 kD的两种抗原。
Comparisons were made between the immune responses evoked during the course of chronic and patent infections of Litomosoides sigmodontis in susceptible BALB/c mice ann non-patent infections in resistant B10.D2 mice. Early antigen specific responses of spleen cells were weak in both mouse strains. However, by day 58 post infection a strong Th2 response, as determined by production of IL-4, IL-5 and IL-10, was observed in BALB/c mice but not in B10.D2 mice. Antibody responses seemed to appear sooner in B10.D2 than in BALB/c mice, and these differentially recognised two antigens of 15 kD and 80 kD.