Association between the MMP-12 gene and systemic sclerosis: role of RS2276109 functional polymorphism in the modulation of skin and pulmonary fibrosis
Association between the MMP-12 gene and systemic sclerosis: role of RS2276109 functional polymorphism in the modulation of skin and pulmonary fibrosis
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MMP-12基因与系统性硬化症之间的关联：RS2276109功能多态性在皮肤和肺纤维化调节中的作用
DOI：
10.1136/ard.2010.129619u
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发表时间：
2010
影响因子：
27.4
通讯作者：
M. Matucci
中科院分区：
文献类型：
--
作者：
M. Manetti;L. Ibba;C. Fatini;S. Guiducci;A. F. Milia;R. Giacomelli;S. Bombardieri;C. Montecucco;R. Abbate;G. Valentini;M. Matucci
系统性硬化症(SSC)是一种威胁生命的自身免疫性疾病，其特征是自身免疫、广泛的微血管受累和皮肤和内脏的进行性纤维化。近年来的研究表明，基质金属蛋白酶-12在肺组织病理性重塑、转化生长因子β诱导的肺纤维化和博莱霉素诱导的肺纤维化中起重要作用。作者先前已经证明，从弥漫性皮肤SSc患者的皮肤分离出的不同类型的细胞(即成纤维细胞和微血管内皮细胞)结构性地过度表达和分泌基质金属蛋白酶-12。…的
Systemic sclerosis (SSc) is a life-threatening autoimmune disease characterised by autoimmunity, widespread microvascular involvement and progressive fibrosis of the skin and internal organs. Recent evidence indicates that matrix metalloproteinase-12 (MMP-12) plays a critical role in pathological lung tissue remodelling and in transforming growth factor β-induced and bleomycin-induced pulmonary fibrosis. The authors have previously shown that different cell types (ie, fibroblasts and microvascular endothelial cells) isolated from the skin of patients with diffuse cutaneous SSc (dcSSc) constitutively overexpress and secrete MMP-12. Of …