Modeling trabecular bone adaptation to local bending load regulated by mechanosensing osteocytes
Modeling trabecular bone adaptation to local bending load regulated by mechanosensing osteocytes
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DOI：
10.1007/s00707-014-1202-5
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发表时间：
2014-10-01
期刊：
影响因子：
2.7
通讯作者：
Adachi, Taiji
中科院分区：
文献类型：
--
作者：
Kameo, Yoshitaka;Adachi, Taiji
松质骨具有复杂的三维多孔微观结构，由柱状或板状小梁组成。小梁的排列在生物体的整个生命周期中被重塑，以适应周围的机械环境。在骨重塑过程中，埋在骨基质中的骨细胞作为机械感觉细胞发挥着关键作用，并根据机械刺激调节破骨细胞骨吸收和成骨细胞骨形成的耦合。在此之前，我们构建了一个结合细胞机械传感和细胞间信号传递的骨小梁骨重塑数学模型，其中骨细胞被认为可以感知间质液的流动，作为调节骨重塑的机械刺激。我们的重塑模拟可以描述单轴载荷下单个柱状小梁的重新定向。在本研究中，为了研究弯曲载荷对骨小梁重塑的影响，我们基于数学模型模拟了单个小梁在循环弯曲载荷下的形态变化。仿真结果表明，弯曲载荷的施加不仅影响板状小梁的形成，而且影响小梁拓扑结构的变化。这些结果表明，小梁的特征形态，如柱状或板状，可能取决于局部的机械环境。
Cancellous bone has a complicated three-dimensional porous microstructure that consists of strut-like or plate-like trabeculae. The arrangement of the trabeculae is remodeled throughout the organism's lifetime to functionally adapt to the surrounding mechanical environment. During bone remodeling, osteocytes buried in the bone matrix are believed to play a pivotal role as mechanosensory cells and help regulate the coupling of osteoclastic bone resorption and osteoblastic bone formation according to the mechanical stimuli. Previously, we constructed a mathematical model of trabecular bone remodeling incorporating cellular mechanosensing and intercellular signal transmission, in which osteocytes are assumed to sense the flow of interstitial fluid as a mechanical stimulus that regulates bone remodeling. Our remodeling simulation could describe the reorientation of a single strut-like trabecula under uniaxial loading. In the present study, to investigate the effects of a bending load on trabecular bone remodeling, we simulated the morphological change in a single trabecula under a cyclic bending load based on our mathematical model. The simulation results showed that the application of the bending load influences not only the formation of the plate-like trabecula but also the changes in trabecular topology. These results suggest the possibility that the characteristic trabecular morphology, such as the strut-like or plate-like form, is determined depending on the local mechanical environment.