Microarray analysis of interferon-regulated genes in SLE
Microarray analysis of interferon-regulated genes in SLE
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DOI：
10.1080/08916930310001625952
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发表时间：
2003-12-01
期刊：
影响因子：
3.5
通讯作者：
Wohlgemuth, J
中科院分区：
文献类型：
--
作者：
Crow, MK;Kirou, KA;Wohlgemuth, J
大约 25 年前，系统性红斑狼疮 (SLE) 中干扰素-α (IFNα) 调节的改变首次被证实。然而，直到最近，该细胞因子家族在 SLE 中的核心作用才受到应有的关注。一些实验室已使用大规模微阵列技术来研究狼疮患者和对照受试者的外周血细胞异质群体中的整体基因表达模式。这些研究的结果表明，IFN 调节的基因是 SLE 单核细胞中最显着过度表达的基因之一。鉴于干扰素对免疫系统功能的多变影响，干扰素活性的增加可能是许多免疫系统改变的原因，这些改变是系统性红斑狼疮的特征并导致自身免疫。确定 SLE 中驱动 IFN 调节基因表达特征的主要 IFN 或其他因素的性质是一个重要的研究领域，可能会导致 SLE 靶向治疗的新方法。
Altered regulation of interferon-alpha (IFNalpha) in systemic lupus erythematosus (SLE) was first demonstrated nearly 25 years ago. However, only recently has due attention been directed towards the central role of this cytokine family in SLE. Several laboratories have used large-scale microarray technology to study global gene expression patterns in heterogeneous populations of peripheral blood cells from lupus patients and control subjects. The results of these studies demonstrate that IFN-regulated genes are among the most significantly overexpressed in SLE mononuclear cells. In view of the protean effects of IFNs on immune system function, increased activity of IFNs may account for many of the immune system alterations that characterize SLE and contribute to autoimmunity. Definition of the nature of the major IFNs, or other factors, that drive the IFN-regulated gene expression signature noted in SLE is an important area for investigation that may lead to new approaches to targeted therapy of SLE.