Procalcitonin and C-reactive protein levels in community-acquired pneumonia: Correlation with etiology and prognosis
Procalcitonin and C-reactive protein levels in community-acquired pneumonia: Correlation with etiology and prognosis
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DOI：
10.1007/s150100050049
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发表时间：
2000-03-01
期刊：
影响因子：
7.5
通讯作者：
Hansson, LO
中科院分区：
文献类型：
--
作者：
Hedlund, J;Hansson, LO
背景资料：前瞻性研究了入院时血清降钙素原（PCT）和C反应蛋白（CRP）水平作为病因和预后指标的诊断价值。患者：96例患者，50-85岁，在医院接受社区获得性肺炎（CAP）治疗，结果：入院时，所有患者的CRP水平均升高（> 10 mg/l），但只有60例患者（54%）的PCT水平升高（> 0.1 μ g/l）。通过APACHE II评分测量的疾病严重程度与入院时PCT水平密切相关（p = 0.006），但与CRP无关。9例非典型病原体引起的肺炎患者中有8例PCT水平< 0.5 μ g/l，而27例经典细菌病原体（主要是肺炎链球菌）引起的肺炎患者中有6例PCT水平< 0.5 μ g/l（p = 0.03）。CRP水平和病因之间没有这样的相关性被发现。结论：我们的数据表明，在入院的患者与CAP，PCT的测量提供有关疾病的严重程度的信息，并可能有助于医生区分典型的细菌性病因，从非典型病因，从而选择适当的初始抗生素治疗。
Background: The diagnostic value of admission serum levels of procalcitonin (PCT) and C-reactive protein (CRP) as indicators of the etiology and prognosis was prospectively investigated.Patients: 96 patients, 50-85 years of age, treated in the hospital for community-acquired pneumonia (CAP),Results: On admission, all patients had elevated CRP levels (> 10 mg/l), but only 60 patients (54%) had elevated PCT levels (> 0.1 mu g/l). The severity of disease measured by APACHE II score was strongly associated with admission levels of PCT (p = 0.006), but not with CRP. Eight of nine patients with pneumonia caused by atypical agents had PCT levels < 0.5 mu g/l compared with 6/27 patients with pneumonia caused by classic bacterial pathogens, mainly Streptococcus pneumoniae (p = 0.03). No such correlation between CRP levels and etiology was found.Conclusion: Our data indicate that in patients admitted to the hospital with CAP, measurement of PCT gives information about the severity of the disease, and may aid the physician to differentiate typical bacterial etiology from atypical etiology, and thereby to choose appropriate initial antibiotic treatment.