Inherited chromosomally integrated HHV-6 possibly modulates human gene expression
Inherited chromosomally integrated HHV-6 possibly modulates human gene expression
复制标题
遗传性染色体整合的 HHV-6 可能调节人类基因表达
DOI：
10.1007/s11262-020-01745-5
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发表时间：
2020
期刊：
影响因子：
1.6
通讯作者：
Sato Kei
中科院分区：
文献类型：
--
作者：
Kumata Ryuichi;Ito Jumpei;Sato Kei
大约1%的人口在基因组中拥有人类疱疹病毒6A和6B(HHV-6A/B)的拷贝。这种病毒成分被称为遗传性染色体整合型HHV-6A/B(iciHHV-6A/B)，在它们的所有细胞中都被编码。最近的一项研究表明，iciHHV-6A/B有可能增强对HHV-6的免疫应答。然而，目前尚不清楚iciHHV-6A/B是否会影响人类的基因表达。在这里，我们使用从各种人体组织获得的数据集进行全局转录组分析。我们分别检测了2个和4个iciHHV-6A和iciHHV-6B阳性的个体，发现iciHHV-6A/B在人体内的转录表达是零星的。转录组分析确定了在iciHHV-6A/B阳性和阴性个体之间差异表达的人类基因。特别是，一些编码免疫球蛋白的基因在iciHHV-6A/B阳性个体的乙状结肠中的表达减少。我们的研究结果提示，iciHHV-6A/B可能与人类的健康维护有关。
Approximately, 1% of human population possesses a copy of human herpesvirus 6A and 6B (HHV-6A/B) in the genome. This viral element is referred to as inherited chromosomally integrated HHV-6A/B (iciHHV-6A/B) and is encoded in all of their cells. A recent study revealed that iciHHV-6A/B potentially increases the immune responses against HHV-6. However, it remains unclear whether iciHHV-6A/B affects human gene expression. Here, we perform global transcriptome analysis using the datasets obtained from various human tissues. We detected two and four individuals positive for iciHHV-6A and iciHHV-6B, respectively, and revealed that the transcriptional expression of iciHHV-6A/B was sporadic in the human body. Transcriptome analysis identified the human genes differentially expressed between iciHHV-6A/B-positive and -negative individuals. Particularly, the expression of some genes encoding immunoglobulins decreased in sigmoid colon of iciHHV-6A/B-positive individuals. Our findings suggest that iciHHV-6A/B may be associated with human health maintenance.