Emerging MRI Techniques to Redefine Treatment Response in Patients With Glioblastoma
Emerging MRI Techniques to Redefine Treatment Response in Patients With Glioblastoma
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DOI：
10.1002/jmri.27105
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发表时间：
2020-03-19
影响因子：
4.4
通讯作者：
Mohan, Suyash
中科院分区：
文献类型：
--
作者：
Goncalves, Fabricio Guimaraes;Chawla, Sanjeev;Mohan, Suyash
胶质母细胞瘤是最常见和最恶性的原发性脑肿瘤。尽管积极的多模式治疗，其预后仍然很差。尽管MRI的不断发展为我们提供了诊断和理解肿瘤生物学的新见解，但治疗后的反应评估仍然具有挑战性。我们相信，从先进的神经影像技术的额外信息的整合，可以进一步提高常规MRI的诊断准确性。在这篇文章中，我们回顾了先进的神经影像学技术，如扩散加权成像，扩散张量成像，灌注加权成像，质子磁共振波谱，化学交换饱和转移的特点和评价治疗反应的胶质母细胞瘤患者的效用。我们还将讨论在临床环境中使用这些技术的现有挑战和局限性，以及避免未来研究设计、数据采集和分析中陷阱的可能解决方案。证据等级2技术疗效阶段3
Glioblastoma is the most common and most malignant primary brain tumor. Despite aggressive multimodal treatment, its prognosis remains poor. Even with continuous developments in MRI, which has provided us with newer insights into the diagnosis and understanding of tumor biology, response assessment in the posttherapy setting remains challenging. We believe that the integration of additional information from advanced neuroimaging techniques can further improve the diagnostic accuracy of conventional MRI. In this article, we review the utility of advanced neuroimaging techniques such as diffusion-weighted imaging, diffusion tensor imaging, perfusion-weighted imaging, proton magnetic resonance spectroscopy, and chemical exchange saturation transfer in characterizing and evaluating treatment response in patients with glioblastoma. We will also discuss the existing challenges and limitations of using these techniques in clinical settings and possible solutions to avoiding pitfalls in study design, data acquisition, and analysis for future studies.Level of Evidence 2Technical Efficacy Stage 3