Inorganic chemistry in nuclear imaging and radiotherapy: current and future directions
Inorganic chemistry in nuclear imaging and radiotherapy: current and future directions
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DOI：
10.1524/ract.2012.1964
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发表时间：
2012-01-01
影响因子：
1.8
通讯作者：
Jurisson, S. S.
中科院分区：
文献类型：
--
作者：
Carroll, V.;Demoin, D. W.;Jurisson, S. S.
放射性金属在诊断和治疗放射性药物方面发挥着重要作用。这一放射化学领域涉及多学科，包括放射性金属的生产、放射性金属与其靶的分离、在生物稳定环境中络合放射性金属的螯合设计、放射性金属在体内部位的特定靶向，以及所产生的放射性药物的核成像和/或放射治疗应用。从历史的角度描述了无机化学在含放射性金属的成像和治疗剂的设计和应用中的关键重要性，并展望了未来的发展方向。
Radiometals play an important role in diagnostic and therapeutic radiopharmaceuticals. This field of radiochemistry is multidisciplinary, involving radiometal production, separation of the radiometal from its target, chelate design for complexing the radiometal in a biologically stable environment, specific targeting of the radiometal to its in vivo site, and nuclear imaging and/or radiotherapy applications of the resultant radiopharmaceutical. The critical importance of inorganic chemistry in the design and application of radiometal-containing imaging and therapy agents is described from a historical perspective to future directions.