STUDIES OF SARCOLEMMAL INTEGRITY IN MYOPATHIC MUSCLE
STUDIES OF SARCOLEMMAL INTEGRITY IN MYOPATHIC MUSCLE
复制标题
DOI：
10.1212/wnl.28.7.670
复制
发表时间：
1978-01-01
期刊：
影响因子：
9.9
通讯作者：
FULTHORPE, JJ
中科院分区：
文献类型：
--
作者：
BRADLEY, WG;FULTHORPE, JJ
用细胞外Procion Yellow进行的肌膜完整性研究证明，在Duchenne营养不良和豚鼠维生素E缺乏性肌病中，高比例的肌纤维存在结构缺陷。在这些条件下，染料进入纤维的频率高于对照组。在染料的主要渗透区域发生肌纤维凝集。在这些条件下，体内似乎可能发生肌膜缺陷，使高浓度的Ca进入肌浆，从而导致纤维损伤。这些肌膜缺陷的生化基础仍有待阐明。股内侧肌活检可能证明是有用的准备肢体肌肉在体外生理研究。
Studies of sarcolemmal integrity with extracellular Procion Yellow gave evidence of structural defects in a high percentage of muscle fibers in Duchenne dystrophy and in vitamin E-deficiency myopathy in the guinea pig. The dye entered fibers in these conditions more often than in controls. Myofibrillary clumping occurred in the region of major penetration of the dye. It seems likely that sarcolemmal defects occur in vivo in these conditions, allowing the entry of high concentrations of Ca into the sarcoplasm with consequent fiber damage. The biochemical basis of these sarcolemmal defects remains to be elucidated. Biopsy of the vastus medialis muscle may prove useful in preparing a limb muscle for in vitro physiologic studies.