Non-malaria fevers in a high malaria endemic area of Ghana.
Non-malaria fevers in a high malaria endemic area of Ghana.
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DOI：
10.1186/s12879-016-1654-4
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发表时间：
2016-07-11
影响因子：
3.7
通讯作者：
Chandramohan D
中科院分区：
文献类型：
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作者：
Asante KP;Owusu-Agyei S;Cairns M;Boamah E;Manu G;Twumasi M;Gyasi R;Adjei G;Kayan K;Mahama E;Dosoo DK;Koram K;Greenwood B;Chandramohan D
人们越来越多地认识到撒哈拉以南非洲儿童非疟疾发热 [非疟疾发热，NMF] 的重要性。我们调查了暴露相关因素和胎盘疟疾对加纳疟疾传播高发地区金坦波儿童非疟疾发烧风险的影响。 2008 年至 2011 年间，我们招募了 1855 名新生儿，并对其进行了至少 12 个月的随访。疾病发作是通过被动病例检测来发现的。主要分析涵盖了从出生到 12 个月大的时期，并对一小部分儿童进行了长达 24 个月的探索性分析。出生第一年（第一年和随后）所有 NMF 发作的发生率为每儿童年 1.60（95% CI 1.54，1.66）。低出生体重婴儿[调整后风险比 (aHR) 1.22 (95% CI 1.04–1.42) p = 0.012]、来自社会经济地位较差家庭的婴儿 [aHR 1.22 (95% CI 1.02–1.46) p = 0.027] 和居住距离最远的婴儿 NMF 发生率较高。医疗机构 [aHR 1.20 (95% CI 1.01–1.43) p = 0.037]。在患有或不患有胎盘疟疾的母亲所生的婴儿中，所有 NMF 发作的发生率相似 [aHR 0.97 (0.87, 1.08; p = 0.584)]。研究地区婴儿期 NMF 的发病率较高。 NMF 的发病率与低出生体重和较差的社会经济地位有关，但与胎盘疟疾无关。本文的在线版本 (doi:10.1186/s12879-016-1654-4) 包含补充材料，可供授权用户使用。
The importance of fevers not due to malaria [non–malaria fevers, NMFs] in children in sub-Saharan Africa is increasingly being recognised. We have investigated the influence of exposure-related factors and placental malaria on the risk of non-malaria fevers among children in Kintampo, an area of Ghana with high malaria transmission. Between 2008 and 2011, a cohort of 1855 newborns was enrolled and followed for at least 12 months. Episodes of illness were detected by passive case detection. The primary analysis covered the period from birth up to 12 months of age, with an exploratory analysis of a sub-group of children followed for up to 24 months. The incidence of all episodes of NMF in the first year of life (first and subsequent) was 1.60 per child-year (95 % CI 1.54, 1.66). The incidence of NMF was higher among infants with low birth weight [adjusted hazard ratio (aHR) 1.22 (95 % CI 1.04–1.42) p = 0.012], infants from households of poor socio-economic status [aHR 1.22 (95 % CI 1.02–1.46) p = 0.027] and infants living furthest from a health facility [aHR 1.20 (95 % CI 1.01–1.43) p = 0.037]. The incidence of all episodes of NMF was similar among infants born to mothers with or without placental malaria [aHR 0.97 (0.87, 1.08; p = 0.584)]. The incidence of NMF in infancy is high in the study area. The incidence of NMF is associated with low birth weight and poor socioeconomic status but not with placental malaria. The online version of this article (doi:10.1186/s12879-016-1654-4) contains supplementary material, which is available to authorized users.