Combination Strategies to Enhance the Efficacy of Antimicrobial Peptides against Bacterial Biofilms.
Combination Strategies to Enhance the Efficacy of Antimicrobial Peptides against Bacterial Biofilms.
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DOI：
10.3389/fmicb.2017.02409
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发表时间：
2017
影响因子：
5.2
通讯作者：
Batoni G
中科院分区：
文献类型：
--
作者：
Grassi L;Maisetta G;Esin S;Batoni G
生物膜相关感染的重大临床意义及其对抗生素治疗固有的耐药性迫切需要开发新的抗生物膜策略。在这方面，抗菌肽（AMP）越来越被认为是开发抗生物膜药物的有前途的模板。事实上，由于其主要作用机制依赖于细菌膜的透化，AMP 对多重耐药细菌和生长缓慢或休眠的生物膜形成细胞也表现出强大的抗菌活性，并且与现有抗生素相比，不易诱发耐药性。此外，通过将 AMP 与传统（抗生素）以及非常规生物活性分子结合，可以大大提高 AMP 的抗菌效力。组合治疗在生物膜的情况下显得特别有吸引力，因为这些微生物群落的异质性需要针对处于不同代谢状态（例如，活跃生长的细胞、休眠细胞）和环境条件（例如，酸性pH、缺乏氧气或营养物）的细胞。因此，作用于不同生物膜成分的不同生物活性分子的组合具有促进生物膜控制和/或根除的潜力。本次综述的目的是强调迄今为止开发的最有前途的组合策略，以增强 AMP 对抗细菌生物膜的治疗潜力。将介绍和讨论 AMP 与传统抗生素、能够分解细胞外基质的化合物、参与生物膜形成的信号通路抑制剂（即群体感应）和其他基于肽的分子结合使用的基本原理和有益结果。
The great clinical significance of biofilm-associated infections and their inherent recalcitrance to antibiotic treatment urgently demand the development of novel antibiofilm strategies. In this regard, antimicrobial peptides (AMPs) are increasingly recognized as a promising template for the development of antibiofilm drugs. Indeed, owing to their main mechanism of action, which relies on the permeabilization of bacterial membranes, AMPs exhibit a strong antimicrobial activity also against multidrug-resistant bacteria and slow-growing or dormant biofilm-forming cells and are less prone to induce resistance compared to current antibiotics. Furthermore, the antimicrobial potency of AMPs can be highly increased by combining them with conventional (antibiotics) as well as unconventional bioactive molecules. Combination treatments appear particularly attractive in the case of biofilms since the heterogeneous nature of these microbial communities requires to target cells in different metabolic states (e.g., actively growing cells, dormant cells) and environmental conditions (e.g., acidic pH, lack of oxygen or nutrients). Therefore, the combination of different bioactive molecules acting against distinct biofilm components has the potential to facilitate biofilm control and/or eradication. The aim of this review is to highlight the most promising combination strategies developed so far to enhance the therapeutic potential of AMPs against bacterial biofilms. The rationale behind and beneficial outcomes of using AMPs in combination with conventional antibiotics, compounds capable of disaggregating the extracellular matrix, inhibitors of signaling pathways involved in biofilm formation (i.e., quorum sensing), and other peptide-based molecules will be presented and discussed.
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影响因子：
--
作者：
de la Fuente-Núñez C;Reffuveille F;Mansour SC;Reckseidler-Zenteno SL;Hernández D;Brackman G;Coenye T;Hancock RE
通讯作者：
Hancock RE
DOI：
10.1007/s10096-011-1188-z
发表时间：
2011-08-01
影响因子：
4.5
作者：
Desbois, A. P.;Coote, P. J.
通讯作者：
Coote, P. J.
影响因子：
5.5
作者：
Grassi L;Maisetta G;Maccari G;Esin S;Batoni G
通讯作者：
Batoni G
影响因子：
5.2
作者：
Grassi L;Di Luca M;Maisetta G;Rinaldi AC;Esin S;Trampuz A;Batoni G
通讯作者：
Batoni G
影响因子：
4.9
作者：
Gopal, Ramamourthy;Kim, Young Gwon;Park, Yoonkyung
通讯作者：
Park, Yoonkyung