The Anatomical Distance of Functional Connections Predicts Brain Network Topology in Health and Schizophrenia
The Anatomical Distance of Functional Connections Predicts Brain Network Topology in Health and Schizophrenia
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DOI：
10.1093/cercor/bhr388
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发表时间：
2013-01-01
期刊：
影响因子：
3.7
通讯作者：
Gogtay, Nitin
中科院分区：
文献类型：
--
作者：
Alexander-Bloch, Aaron F.;Vertes, Petra E.;Gogtay, Nitin
人类大脑是一个嵌入解剖空间的拓扑复杂网络。在此，我们系统地探究了20名健康志愿者和19名儿童期起病精神分裂症（COS）患者在静息态功能磁共振成像大脑网络中，功能连接性、复杂网络拓扑结构以及相连脑区之间的解剖（欧几里得）距离之间的关系。大脑图中连接边平均距离的正常个体间差异与功能网络的拓扑特性变化密切相关。此外，在外侧颞叶、顶叶、背侧前额叶以及内侧前额叶/扣带皮层区域确定了一个连接枢纽俱乐部或子集。在COS中，特别是短距离的功能连接强度降低，因此，阈值化图的全局平均连接距离显著大于正常。正如从正常网络的空间和拓扑特性之间的关系所预测的那样，这种与疾病相关的连接距离成比例增加与COS网络的聚类和模块性降低以及全局效率提高有关。连接距离的组间差异特别定位于多模态联合皮层的连接枢纽。关于精神分裂症的神经发育发病机制，我们认为这些数据与以下解释相符：功能网络组织的空间和拓扑紊乱可能源于精神分裂症中短距离功能连接的过度“修剪”。
The human brain is a topologically complex network embedded in anatomical space. Here, we systematically explored relationships between functional connectivity, complex network topology, and anatomical (Euclidean) distance between connected brain regions, in the resting-state functional magnetic resonance imaging brain networks of 20 healthy volunteers and 19 patients with childhood-onset schizophrenia (COS). Normal between-subject differences in average distance of connected edges in brain graphs were strongly associated with variation in topological properties of functional networks. In addition, a club or subset of connector hubs was identified, in lateral temporal, parietal, dorsal prefrontal, and medial prefrontal/cingulate cortical regions. In COS, there was reduced strength of functional connectivity over short distances especially, and therefore, global mean connection distance of thresholded graphs was significantly greater than normal. As predicted from relationships between spatial and topological properties of normal networks, this disorder-related proportional increase in connection distance was associated with reduced clustering and modularity and increased global efficiency of COS networks. Between-group differences in connection distance were localized specifically to connector hubs of multimodal association cortex. In relation to the neurodevelopmental pathogenesis of schizophrenia, we argue that the data are consistent with the interpretation that spatial and topological disturbances of functional network organization could arise from excessive "pruning" of short-distance functional connections in schizophrenia.