Pathophysiology of adult obstructive sleep apnea.
Pathophysiology of adult obstructive sleep apnea.
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DOI：
10.1513/pats.200707-114mg
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发表时间：
2008-02-15
期刊：
影响因子：
--
通讯作者：
Malhotra, Atul
中科院分区：
文献类型：
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作者：
Eckert, Danny J;Malhotra, Atul
阻塞性睡眠呼吸暂停（OSA）是一种常见的疾病，其特征是睡眠期间咽部气道反复狭窄或塌陷。这种疾病与主要的合并症有关，包括白天过度嗜睡和心血管疾病风险增加。潜在的病理生理学是多因素的，个体之间可能差异很大。重要的风险因素包括肥胖、男性和衰老。然而，这些危险因素的生理机制还不清楚。这篇简短的综述总结了目前对成人OSA病理生理学的认识，并强调了主要危险因素的潜在机制。此外，一些病理生理特征与OSA，可能调节疾病的严重程度进行了说明。最后，潜在的新的治疗策略，基础上进一步了解的基础病理生理学，也讨论了刺激研究的想法，在知识缺乏的领域的最终目的。
Obstructive sleep apnea (OSA) is a common disorder characterized by repetitive narrowing or collapse of the pharyngeal airway during sleep. The disorder is associated with major comorbidities including excessive daytime sleepiness and increased risk of cardiovascular disease. The underlying pathophysiology is multifactorial and may vary considerably between individuals. Important risk factors include obesity, male sex, and aging. However, the physiological mechanisms underlying these risk factors are not clearly understood. This brief review summarizes the current understanding of OSA pathophysiology in adults and highlights the potential mechanisms underlying the principal risk factors. In addition, some of the pathophysiological characteristics associated with OSA that may modulate disease severity are illustrated. Finally, the potential for novel treatment strategies, based on an improved understanding of the underlying pathophysiology, is also discussed with the ultimate aim of stimulating research ideas in areas where knowledge is lacking.