Recent tobacco use has widespread associations with adolescent white matter microstructure.
Recent tobacco use has widespread associations with adolescent white matter microstructure.
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DOI：
10.1016/j.addbeh.2019.106152
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发表时间：
2020-02
影响因子：
4.4
通讯作者：
R. Thayer;Natasha S. Hansen;S. Prashad;H. Karoly;F. Filbey;A. Bryan;Sarah W. Feldstein Ewing
中科院分区：
文献类型：
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作者：
R. Thayer;Natasha S. Hansen;S. Prashad;H. Karoly;F. Filbey;A. Bryan;Sarah W. Feldstein Ewing
鉴于酒精、大麻和烟草在青春期的普遍使用，重要的是探索这三种物质与脑结构的相关性。目的在大样本青少年中确定最近酒精、大麻和烟草使用与白质和灰质之间的关系。设计、背景和参与者收集了Inn= 200名14-18岁的青少年的MRI数据(M= 15.82 岁；67%男性；61%西班牙裔/拉丁裔)。在过去的一个月里，参与者平均每1.01天饮酒2.05杯，每6.98天吸食大麻0.64 克，每12.32天吸食2.49支香烟。主要结果和测量方法一般线性模型被用来检验过去30天酒精、大麻和烟草的平均量、年龄、性别和按物质在骨骼白质中的相互作用(各向异性分数和轴向、径向、和平均弥散系数)和基于体素的灰质形态计量学(体积/密度)。结果吸烟与白质完整性(径向和平均弥散系数)呈负相关，在下纵束和上纵束的影响最大。大麻的使用与左上纵束中的一小簇白质完整性(轴向弥散率)呈负相关。没有观察到最近饮酒与白质或灰质总体之间的关联，但交互作用显示女性饮酒与白质之间存在显著的负相关。结论和相关性值得注意的是，最近吸烟，特别是考虑到电子烟/电子烟在这个年龄段的流行，在这个样本的青少年中，与大脑结构有广泛的关联。
ImportanceGiven the prevalence of alcohol, cannabis, and tobacco use during adolescence, it is important to explore the relative relationship of these three substances with brain structure.ObjectiveTo determine associations between recent alcohol, cannabis, and tobacco use and white and gray matter in a large sample of adolescents.Design, Setting, and ParticipantsMRI data were collected inN= 200 adolescents ages 14–18 (M= 15.82 years; 67% male; 61% Hispanic/Latino). On average, during the past month, participants reported consuming 2.05 drinks per 1.01 drinking day, 0.64 g per 6.98 cannabis use days, and 2.49 cigarettes per 12.32 smoking days.Main Outcomes and MeasuresGeneral linear models were utilized to examine past 30-day average quantities of alcohol, cannabis, and tobacco use, age, sex, and sex by substance interactions in skeletonized white matter (fractional anisotropy and axial, radial, and mean diffusivity) and voxel-based morphometry of gray matter (volume/density).ResultsTobacco use was negatively associated with white matter integrity (radial and mean diffusivity) with peak effects in inferior and superior longitudinal fasciculi. Cannabis use was negatively associated with white matter integrity (axial diffusivity) in a small cluster in the left superior longitudinal fasciculus. No associations were observed between recent alcohol use and white or gray matter overall, but interactions showed significant negative associations between alcohol use and white matter in females.Conclusions and RelevanceIt is important to note that recent tobacco use, particularly given the popularity of e-tobacco/vaping in this age group, had widespread associations with brain structure in this sample of adolescents.