Physiological study of neurons in the dorsal and posteroventral cochlear nucleus of the unanesthetized cat.
Physiological study of neurons in the dorsal and posteroventral cochlear nucleus of the unanesthetized cat.
复制标题
未麻醉猫背侧和后腹侧耳蜗核神经元的生理研究。
DOI：
10.1152/jn.1987.57.2.414
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发表时间：
1987
影响因子：
2.5
通讯作者：
Kettner,RE
中科院分区：
文献类型：
--
作者：
Rhode,WS;Kettner,RE
本实验测定了猫耳蜗后腹核（PVCN）和背核（DCN）神经元对长音和短音的反应。这些结果进行了比较，最近的研究在巴比妥酸盐麻醉猫在同一实验室进行类似的刺激和分析程序。在之前使用麻醉动物的研究中观察到的每种反应模式（刺激后时间直方图到短音）也在没有麻醉剂的情况下观察到。匡威亦然：在未麻醉的猫中没有观察到新的反应模式。这对于间隔直方图、反应面积、isorate曲线和频率扫描数据也是如此。有些神经元很难归类到现有的耳蜗核反应模式的描述。举例来说：初级样、起始、暂停和积累反应模式也可以显示出类似斩波器的特性;起始抑制、暂停和积累神经元似乎形成反应连续体，而不是作为单独的反应类别存在;具有低特征频率（CF）的起始神经元通常在低于约1，000 Hz时显示出持续和强锁相反应。此外，单个神经元往往表现出一个以上的响应模式，这取决于声刺激的强度和频率。在麻醉状态下也观察到这些模糊性。PVCN内的发作神经元似乎非常适合于时间和强度信息的编码。在低刺激频率下，它们通常对纯音刺激的每个周期都有反应，并在耳蜗核中表现出最高程度的锁相。与大多数其他耳蜗核神经元相关的30- 40-dB动态范围相比，与许多起始神经元相关的动态范围可以超过80 dB。发作的神经元表现出类似的活动范围内的麻醉猫。神经元在DCN的反应特性，是更复杂的比在PVCN。反应模式可以从持续兴奋到完全抑制，并且在CF附近更经常是非单调的。DCN神经元可以在频域中显示出明确的调谐，并且可以用于对频谱信息进行编码，但是似乎不太适合对时间或强度信息进行编码，因为它们是弱锁相的并且具有相对小的动态范围。当DCN神经元“劈”时，它们通常比PVCN神经元慢。在麻醉猫中记录的DCN神经元的行为类似。特定反应模式的相对频率确实随麻醉状态而变化。（400字处截断摘要）
The responses of neurons in the posteroventral (PVCN) and dorsal (DCN) cochlear nucleus of the unanesthetized cat were determined for both long and short tones. These results were compared with recent studies in the barbiturate-anesthetized cat conducted in the same laboratory using similar stimuli and analysis programs. Every response pattern (poststimulus time histogram to short tones), which has been observed in previous studies using anesthetized animals, was also observed without anesthetic. The converse was also true: no novel response patterns were observed in the unanesthetized cat. This was also true for interval histogram, response area, isorate curve, and frequency sweep data. Some neurons were difficult to classify into existing descriptions of cochlear nucleus response patterns. For example: primary-like, onset, pauser, and buildup response patterns could also show chopper-like properties; onset-inhibitory, pauser, and buildup neurons appeared to form a response continuum rather than exist as separate response categories; and onset neurons with low characteristic frequencies (CFs) often showed sustained and strongly phase-locked responses below approximately 1,000 Hz. In addition, single neurons often showed more than one response pattern depending on the intensity and frequency of the acoustic stimulus. These ambiguities were also observed under anesthetic. Onset neurons within the PVCN appear to be well suited for the encoding of temporal and intensity information. At low stimulus frequencies they often respond to every cycle of a pure tone stimulus and exhibit the highest degree of phase-locking in the cochlear nucleus. The dynamic ranges associated with many onset neurons can exceed 80 dB compared with the 30- to 40-dB dynamic ranges associated with most other cochlear nucleus neurons. Onset neurons show a similar range of activities in the anesthetized cat. Neurons in the DCN have response properties that are more complex than those seen in the PVCN. Response patterns can change from sustained excitation to complete inhibition and are more often nonmonotonic near CF. DCN neurons can show well-defined tuning in the frequency domain and may be used to encode spectral information, but appear to be poorly suited for encoding temporal or intensity information as they are weakly phase-locked and have relatively small dynamic ranges. When DCN neurons "chop" they usually do so more slowly than do PVCN neurons. DCN neurons recorded in the anesthetized cat behave similarly. The relative frequency of a particular response pattern did vary with anesthetic state.(ABSTRACT TRUNCATED AT 400 WORDS)