The prognostic value of hypoxia markers in T2-staged oral tongue cancer
The prognostic value of hypoxia markers in T2-staged oral tongue cancer
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DOI：
10.1016/j.oraloncology.2008.03.017
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发表时间：
2009-01-01
期刊：
影响因子：
4.8
通讯作者：
Kim, Sang Yoon
中科院分区：
文献类型：
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作者：
Roh, Jong-Lye;Cho, Kyung-Ja;Kim, Sang Yoon
肿瘤缺氧与头颈癌患者较差的预后相关，但人们对口腔舌癌缺氧生物标志物知之甚少。我们评估了缺氧生物标志物和临床病理变量是否是 T2 期口腔舌鳞状细胞癌 (SCC) 患者的预后预测因素。组织微阵列是由 43 名 T2 期舌 SCC 患者的福尔马林固定肿瘤块构建而成，这些患者经过手术切除和颈清扫术治疗。组织样本用缺氧诱导因子 (HIF)-1 α、HIF-2 α、碳酸酐酶 (CA)-9、葡萄糖转运蛋白 (GLUT)-1 和促红细胞生成素受体 (EPOR) 的单克隆抗体进行染色。地方性的。通过Kaplan-Meier方法计算对照率和生存率，并通过单变量和多变量分析计算预后因素。肿瘤厚度与 CA-9 和 GLUT-1 的表达相关，淋巴结分类与 GLUT-1 的表达相关。淋巴结转移率为51%，5年局部控制率和疾病特异性生存率（DSS）分别为59%和69%。单因素分析显示HIF-1α和EPOR的表达与DSS显着相关。多变量分析表明 EPOR 表达是 DSS 的独立预测因子（P = 0.030）。 EPOR 表达可能是 T2 期口腔舌 SCC 患者 DSS 的独立预测因子。 (C) 2008 Elsevier Ltd. 保留所有权利。
Tumor hypoxia is associated with poorer outcome in patients with head and neck carcinomas, but little is known about hypoxia biomarkers in oral tongue cancer. We evaluated whether hypoxia biomarkers and clinicopathologic variables were prognostic predictors in patients with T2-staged squamous cell carcinoma (SCC) of the oral tongue. Tissue microarrays were constructed from formatin-fixed tumor blocks of 43 patients with T2-staged tongue SCCs treated by surgical resection and neck dissection. Tissue samples were stained with monoclonal antibodies to hypoxia-inducible factor (HIF)-1 alpha, HIF-2 alpha, carbonic anhydrase (CA)-9, glucose transporter (GLUT)-1, and erythropoietin receptor (EPOR). Locoregional. control and survival rates were calculated by the Kaplan-Meier method, and prognostic factors were calculated from uni- and multivariate analyses. Tumor thickness was correlated with expression of CA-9 and GLUT-1 and nodal classification was correlated with GLUT-1 expression. The nodal metastasis rate was 51%, and the 5-year locoregional control and disease-specific survival (DSS) rates were 59% and 69%, respectively. Univariate analysis showed that HIF-1 alpha and EPOR expression were significantly related to DSS. Multivariate analysis showed that EPOR expression was an independent predictor of DSS (P = 0.030). EPOR expression may be an independent predictor for DSS in patients with T2-staged SCC of the oral tongue. (C) 2008 Elsevier Ltd. All rights reserved.