Optical coherence tomography-based decision making in exudative age-related macular degeneration: comparison of time- vs spectral-domain devices.
Optical coherence tomography-based decision making in exudative age-related macular degeneration: comparison of time- vs spectral-domain devices.
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作者：
Cukras, C.;Wang, Y. D.;Meyerle, C. B.;Forooghian, F.;Chew, E. Y.;Wong, W. T.
关键词：
确定光学相干断层扫描 (OCT) 设备类型是否影响渗出性年龄相关性黄斑变性 (AMD) 背景下 OCT 成像的临床分级。在同一次就诊中，时域 Stratus™ OCT 系统和谱域 Cirrus™ OCT 系统获得了 49 名活动性渗出性 AMD 患者的 96 配对 OCT 扫描。三名独立的分级员对每次扫描判断是否存在视网膜内液 (IRF) 或视网膜下液 (SRF)。评估了分级者共识的程度，并分析了系统检测疾病活动存在的能力。 Cirrus™ OCT 比 Stratus OCT 产生了更高程度的年级间共识，所有分析参数的组内相关系数 (ICC) 更高。 Cirrus™ OCT 与 Stratus™ OCT 系统的成对比较显示，与基于 Stratus™ 的分级相比，基于 Cirrus™ 的分级更频繁地报告 SRF 和 IRF 的存在，并以更高的比率 (p<0.05) 检测到总体新生血管活动。时域 (Stratus™) 与谱域 (Cirrus™) OCT 系统的选择对渗出性 AMD 的临床决策具有可衡量的影响。谱域 OCT 系统可能能够在临床解释中达成更多共识，并且在特定情况下，可以检测时域系统未检测到的疾病活动。采用基于 OCT 的渗出性 AMD 临床评估的临床试验可能需要在规划和分析中考虑这些系统间差异。
To determine if optical coherence tomography (OCT) device-type influences clinical grading of OCT imaging in the context of exudative age-related macular degeneration (AMD). Ninety-six paired OCT scans from 49 patients with active exudative AMD were obtained on both the time-domain Stratus™ OCT system and the spectral-domain Cirrus™ OCT system at the same visit. Three independent graders judged each scan for the presence of intraretinal fluid (IRF) or subretinal fluid (SRF). The degree of grader consensus was evaluated and the ability of the systems to detect the presence of disease activity was analyzed. Cirrus™ OCT generated a higher degree of inter-grader consensus than Stratus OCT with higher intraclass correlation coefficients (ICC) for all parameters analyzed. A pair-wise comparison of Cirrus™ OCT to Stratus™ OCT systems revealed that Cirrus™-based gradings more frequently reported the presence of SRF and IRF and detected overall neovascular activity at a higher rate (p<0.05) compared to Stratus™-based gradings The choice of time-domain (Stratus™) versus spectra-domain (Cirrus™) OCT systems has a measurable impact on clinical decision making in exudative AMD. Spectral-domain OCT systems may be able to generate more consensus in clinical interpretation and, in particular cases, detect disease activity not detected by time-domain systems. Clinical trials employing OCT-based clinical evaluations of exudative AMD may need to account for these inter-system differences in planning and analysis.
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影响因子：
13.7
作者：
Hee, MR;Baumal, CR;Fujimoto, JG
通讯作者：
Fujimoto, JG
影响因子：
13.7
作者：
Kaiser, Peter K.;Blodi, Barbara A.;Acharya, Nisha R.
通讯作者：
Acharya, Nisha R.
影响因子：
13.7
作者：
Holz, FG;Jorzik, J;Unnebrink, K
通讯作者：
Unnebrink, K
影响因子：
4.2
作者：
Jaffe, GJ;Caprioli, J
通讯作者：
Caprioli, J
影响因子：
4.4
作者：
Bernardes, Rui;Santos, Torcato;Cunha-Vaz, Jose
通讯作者：
Cunha-Vaz, Jose