Characteristics of natural antibody-secreting cells.
Characteristics of natural antibody-secreting cells.
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DOI：
10.1111/nyas.12799
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发表时间：
2015-12
影响因子：
5.2
通讯作者：
Baumgarth N
中科院分区：
文献类型：
--
作者：
Savage HP;Baumgarth N
天然IgM在保护免受病原体和预防自身免疫中起着关键作用。虽然它的重要性已在许多不同的设置，其起源是不完全理解。本文综述了主要来源于B-1细胞系的天然IgM抗体分泌细胞（ASCs）的特性。B-1细胞在发育过程中以多波形式产生，主要发生在胎儿期和胎儿后早期。发育时间点可以影响它们的库：产前B-1细胞主要表达生殖系编码的库，而出生后发育的B-1细胞可以表达具有更大程度变异的IG。脾和骨髓是IgM天然分泌的主要部位，但体腔不是。在这些组织中可以发现IgM抗体的ASC的异质性群体，虽然一些ASC表达B-1淋巴细胞的经典标记，但其他ASC表达终末分化的浆细胞的标记。更好地了解这些不同的天然IgM ASC的特性可以帮助他们未来的治疗开发。
Natural IgM plays a critical role in protection from pathogens and the prevention of autoimmunity. While its importance has been shown in many different settings, its origins are incompletely understood. This review focuses on the properties of the natural IgM antibody-secreting cells (ASCs), which arise mainly from the B-1 cell lineage. B-1 cells are generated in multiple waves during development, mostly in the fetal and early postfetal periods. The developmental time points can affect their repertoire: prenatal B-1 cells express a mainly germ line–encoded repertoire, while postnatally developing B-1 cells can express Ig with a greater degree of variation. Spleen and bone marrow, but not the body cavities, are primary sites of natural IgM secretion. Within these tissues heterogeneous populations of IgM ASCs can be found. While some ASCs express classical markers of B-1 lymphocytes, others express those of terminally differentiated plasma cells. A better understanding of the properties of these different natural IgM ASCs could aid their future therapeutic exploitation.