Rates of depression in individuals with pathologic but not clinical Alzheimer disease are lower than those in individuals without the disease: findings from the Baltimore Longitudinal Study on Aging (BLSA).
Rates of depression in individuals with pathologic but not clinical Alzheimer disease are lower than those in individuals without the disease: findings from the Baltimore Longitudinal Study on Aging (BLSA).
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患有病理性但非临床阿尔茨海默病的个体的抑郁症发病率低于未患该病的个体：巴尔的摩老龄化纵向研究 (BLSA) 的发现。
DOI：
10.1097/wad.0b013e3181461932
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发表时间：
2007
影响因子：
2.1
通讯作者：
Lyketsos,ConstantineG
中科院分区：
文献类型：
--
作者：
Morgan,MelissaD;Mielke,MichelleM;O'Brien,Richard;Troncoso,JuanC;Zonderman,AlanB;Lyketsos,ConstantineG
阿尔茨海默病（AD）中重度抑郁症的患病率增加，但目前这种关联的基础仍不清楚。本研究通过对来自巴尔的摩老龄化纵向研究的4组参与者进行尸检，检查了抑郁症的发生率：（1）无阿尔茨海默病的认知正常对照组，（2）有阿尔茨海默病的认知正常个体，（3）轻度认知障碍伴阿尔茨海默病的个体，（4）临床诊断为痴呆伴阿尔茨海默病的个体。使用流行病学研究中心抑郁量表评估抑郁症状。患有阿尔茨海默病但在死亡前没有认知下降的个体的抑郁率显著低于没有阿尔茨海默病病理的认知正常对照组和患有阿尔茨海默病病理加上痴呆临床诊断的个体。这些结果表明，抑郁症是一个危险因素，AD的病理存在的AD，但抑郁症不是一个危险因素的AD病理。
The prevalence of major depression is increased in Alzheimer disease (AD), but currently the basis of this association remains unclear. The present study examined rates of depression in 4 groups of participants with postmortem examination from the Baltimore Longitudinal Study of Aging:(1) cognitively normal controls with no Alzheimer pathology,(2) cognitively normal individuals with Alzheimer pathology,(3) individuals with mild cognitive impairment plus Alzheimer pathology,(4) individuals with clinical diagnoses of dementia plus Alzheimer pathology. Depressive symptoms were assessed using the Center for Epidemiologic Studies Depression Scale. Individuals with Alzheimer pathology but no cognitive decline before death had significantly lower rates of depression than cognitively normal controls with no Alzheimer pathology and individuals with Alzheimer pathology plus clinical diagnoses of dementia. These findings suggest that depression is a risk factor for AD in the presence of AD pathology, but depression is not a risk factor for AD pathology.