RELATIONSHIP BETWEEN SPECIFIC-GRAVITY, WATER-CONTENT, AND SERUM-PROTEIN EXTRAVASATION IN VARIOUS TYPES OF VASOGENIC BRAIN EDEMA
RELATIONSHIP BETWEEN SPECIFIC-GRAVITY, WATER-CONTENT, AND SERUM-PROTEIN EXTRAVASATION IN VARIOUS TYPES OF VASOGENIC BRAIN EDEMA
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DOI：
10.1007/bf00695604
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发表时间：
1984-01-01
影响因子：
12.7
通讯作者：
HOSSMANN, KA
中科院分区：
文献类型：
--
作者：
BOTHE, HW;BODSCH, W;HOSSMANN, KA
在猫中通过冷损伤（6只动物）、脑肿瘤（5只动物）和脑水肿（6只动物）诱导血管源性脑水肿。水和电解质含量，比重，血容量，外渗的血清蛋白的量进行了测定，从灰色和白色物质在不同的距离病变的小组织样本。水肿严格限于受累半球的白色物质，并从病变向更外围区域下降。其特征是血清蛋白外渗，水和钠含量增加，钾和血容量变化很小或不可预测。计算的水肿液的Na含量在129和135 μ eq/ml之间变化，血清蛋白含量在8.1和11.9 mg/ml之间变化。在所有3种类型的水肿中，比重和含水量与计算的回归的相同斜率和截距密切相关（y = 1.119 - 0.0011x，r = -0.91）。显然，水肿性白色物质比重的主要分母是含水量，并且这种关系不会因血容量或血清蛋白含量的变化而显著改变。
Vasogenic brain edema was induced in cats by cold injury (6 animals), brain tumors (5 animals), and brain abscesses (6 animals). Water and electrolyte content, specific gravity, blood volume, and the amount of extravasated serum proteins were determined in small tissue samples taken from gray and white matter at various distances from the lesion. Edema was strictly confined to the white matter of the affected hemisphere and declined from the lesion to the more peripheral regions. It was characterized by the extravasation of serum proteins and an increase of the water and Na content with little or unpredictable changes of K and blood volume. The calculated Na content of edema fluid varied between 129 and 135 .mu.eq/ml, and serum protein content between 8.1 and 11.9 mg/ml. In all 3 types of edema, specific gravity and water content correlated closely with the same slope and intercept of the calculated regression (y = 1.119 - 0.0011x, r = -0.91). Evidently, the main denominator of specific gravity of edematous white matter is water content and this relationship is not significantly altered by variations of blood volume or serum protein content.