Sensorimotor gating, working and social memory deficits in mice with reduced expression of the vesicular glutamate transporter VGLUT1
Sensorimotor gating, working and social memory deficits in mice with reduced expression of the vesicular glutamate transporter VGLUT1
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DOI：
10.1016/j.bbr.2011.12.012
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发表时间：
2012-03-17
影响因子：
2.7
通讯作者：
Gass, Peter
中科院分区：
文献类型：
--
作者：
Inta, Dragos;Vogt, Miriam A.;Gass, Peter
谷氨酸是中枢神经系统中主要的兴奋性神经递质。低谷氨酸能状态被认为在精神分裂症的病理生理中起重要作用。谷氨酸在大脑中的释放是由一类囊状谷氨酸转运蛋白VGLUT1-3调节的。其中，VGLUT1是主要表达于新皮层和海马的异构体。在这里，我们通过在精神分裂症相关的几个行为测试中测试VGLUT1表达减少的小鼠，研究了VGLUT1缺乏在产生精神分裂症样异常中的潜在参与。我们发现这些小鼠的行为改变与精神分裂症相关，如工作和社会记忆障碍以及声惊吓反射（ASR）的脉冲前抑制（PPI）缺陷，但在基础条件下运动行为正常。我们的数据对于更好地理解vglut1介导的突触前谷氨酸能神经传递减少在与精神分裂症相关的几种行为异常产生中的作用可能是重要的。(C) 2012 Elsevier B.V.版权所有
Glutamate is the main excitatory neurotransmitter in the central nervous system. A hypoglutamatergic state is believed to play an important role in the pathophysiology of schizophrenia. The release of glutamate in the brain is modulated by a class of vesicular glutamate transporters, VGLUT1-3. Among them, VGLUT1 represents the isoform predominantly expressed in the neocortex and hippocampus. Here we investigated the potential involvement of VGLUT1 deficiency in generating schizophrenia-like abnormalities by testing mice with diminished expression of VGLUT1 in several behavioural tests relevant for schizophrenia. We found behavioural alterations in these mice resembling correlates of schizophrenia, such as working- and social memory impairments and deficits in prepulse inhibition (PPI) of the acoustic startle reflex (ASR), but normal locomotor behaviour under basal conditions. Our data may be important for a better understanding of the contribution of reduced VGLUT1-mediated presynaptic glutamatergic neurotransmission in the generation of several behavioural abnormalities associated with schizophrenia. (C) 2012 Elsevier B.V. All rights reserved.