Nestin-like immunoreactivity of corpora amylacea in aged human brain
Nestin-like immunoreactivity of corpora amylacea in aged human brain
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DOI：
10.1016/s0169-328x(01)00166-8
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发表时间：
2001-10-19
期刊：
影响因子：
--
通讯作者：
Galter, D
中科院分区：
文献类型：
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作者：
Buervenich, S;Olson, L;Galter, D
淀粉体(CA)是老年人大脑中常见的球形小体，常见于脑室室管膜下。我们在帕金森患者和年龄匹配的对照组的尸检脑组织中发现了侧脑室和第四脑室室管膜下的CA簇。使用一种单抗，我们发现CA对神经干细胞的标记物Nestin呈免疫反应，而在被调查的脑区中没有其他结构被这种抗体标记。因此，巢蛋白细丝可能是CA的结构成分，这一发现可能会引发关于它们的生物发生和功能的新假说。(C)2001爱思唯尔科学公司保留所有权利。
Corpora amylacea (CA) are spherical bodies routinely observed throughout the aged human brain, normally found at high frequencies under the ependymal lining of the ventricles. We identified clusters of CA under the ependyma of the lateral and fourth ventricles in post-mortem brain material from Parkinson patients as well as age-matched controls. Using a monoclonal antibody we found CA to be immunoreactive for nestin, a marker of neural stem cells, while no other structures in the investigated brain areas were labeled by this antibody. Nestin filaments are therefore possible structural components of CA, a finding which may trigger new hypotheses regarding their biogenesis and function. (C) 2001 Elsevier Science BY All rights reserved.