Stress: the shared common component in major mental illnesses
Stress: the shared common component in major mental illnesses
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DOI：
10.1016/s0924-9338(05)80184-1
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发表时间：
2005-10-01
影响因子：
7.8
通讯作者：
Dinan, TG
中科院分区：
文献类型：
--
作者：
Dinan, TG
社会心理压力在抑郁症和精神分裂症等主要精神疾病症状的发展和维持中的作用已得到充分证实。在抑郁症中，儿童早期创伤和当前重大生活事件的参与已被广泛研究。大多数抑郁症患者在应激事件后会经历抑郁症发作，此类患者症状的持续通常与持续的社会心理压力有关[10]。在没有负面生活事件的情况下出现抑郁症是不寻常的，至少在病程早期是如此。这种真正的“内源性”发作很少见，往往发生在那些有严重抑郁症家族史和病程晚期的人身上。乔治·布朗在伦敦市中心进行的关键研究中强调了近期生活事件在抑郁症发生中的作用以及缺乏适当的支持结构。患有抑郁症的女性比平均水平更有可能经历过近期的生活事件、家里有几个小孩和一个不支持的伴侣[2]。
The role of psychosocial stress in the development and maintenance of symptoms in major psychiatric disorders such as depression and schizophrenia is well-established. In depression, the involvement of early childhood trauma and current significant life events have been extensively investigated. The majority of depressed patients experience episodes of depression following stressful events and the maintenance of symptoms in such patients is frequently associated with ongoing psychosocial stress [10]. It is unusual, at least early in the course of a patient's illness for depression to be seen in the absence of negative life events. Such truly'endogenous' episodes are rare and tend to occur in those with a strong family history of depression and late in the course of illness.The work of George Brown in his pivotal studies carried out in inner London highlights the role of recent life events in the genesis of depression and the lack of appropriate support structures. Women with depression were far more likely than average to have experienced recent life events, have several young children at home and a non-supportive partner [2].