Peptide synthesis in room temperature ionic liquids
Peptide synthesis in room temperature ionic liquids
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DOI：
10.1016/j.tetlet.2003.12.124
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发表时间：
2004-02-16
影响因子：
1.8
通讯作者：
Plaquevent, JC
中科院分区：
文献类型：
--
作者：
Vallette, H;Ferron, L;Plaquevent, JC
我们证明了使用现代偶联剂的化学肽偶联在室温离子液体中是有效的。这种新方法具有一些优点，特别是在受阻氨基酸的情况下，受阻氨基酸在标准条件下不容易偶联，因为在经典溶剂中偶联时观察到粗肽的高纯度。(C)2004爱思唯尔有限公司保留所有权利。
We demonstrate that chemical peptide coupling using modern coupling agents is efficient in rt ionic liquids. This new approach presents some advantages, especially in the case of hindered amino acids, which are not easy to couple under standard conditions, since high purities for the crude peptides were observed with respect to coupling in classical solvents. (C) 2004 Elsevier Ltd. All rights reserved.