Mechanisms of signal transduction from receptors of type I and type II cytokines
Mechanisms of signal transduction from receptors of type I and type II cytokines
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DOI：
10.1080/15476910601154779
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发表时间：
2007-01-01
影响因子：
3.3
通讯作者：
Fujii, Hodaka
中科院分区：
文献类型：
--
作者：
Fujii, Hodaka
细胞因子在免疫反应的调节中起着关键作用。参与细胞因子信号转导途径的信号蛋白可能是引起异常免疫反应的毒素的潜在靶点。细胞因子与其特定受体的结合可诱导信号转导通路的激活。本文就细胞因子/细胞因子受体系统、细胞因子受体激活的信号通路及其调控机制、细胞因子信号异常引起的病理状态以及近期有待阐明的问题作一综述。
Cytokines play pivotal roles in regulation of immune responses. Signaling proteins involved in cytokine signal transduction pathways can be potential targets of toxins causing aberrant immune responses. Binding of cytokines to their specific receptors induces activation of signal transduction pathways. In this review, an overview of the cytokine/cytokine receptor system, signaling pathways activated by cytokine receptors, their regulation mechanisms, pathological conditions caused by aberrant cytokine signaling, and issues to be elucidated in the near future is provided.