Phase specificity of developmental toxicity after oral administration of mono-n-butyl phthalate in rats
Phase specificity of developmental toxicity after oral administration of mono-n-butyl phthalate in rats
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大鼠口服邻苯二甲酸单丁酯后发育毒性的时相特异性
DOI：
10.1007/bf00212362
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发表时间：
1996
影响因子：
4
通讯作者：
Y. Ogawa
中科院分区：
文献类型：
--
作者：
M. Ema;R. Kurosaka;A. Harazono;H. Amano;Y. Ogawa
本研究的目的是进一步表征邻苯二甲酸单正丁酯（MBuP）的发育毒性，MBuP是邻苯二甲酸正丁基苄基酯（BBP）和邻苯二甲酸二正丁酯（DBP）的主要代谢产物之一。妊娠大鼠在妊娠第7-9天、第10-12天或第13-15天通过胃插管给予MBuP，剂量为500、625或750 mg/kg。在第7-9天和第10-12天以625 mg/kg及以上剂量给予MBuP以及在第13-15天以500 mg/kg及以上剂量给予MBuP的妊娠大鼠中，观察到着床后丢失的发生率显著增加。在妊娠第10-12天给予MBuP时，未发现致畸性证据。在第7-9天和第13-15天以625和750 mg/kg剂量给予MBuP后，发现胎仔外部畸形的发生率显著增加。在第7-9天以500 mg/kg及以上剂量和第13-15天以625 mg/kg及以上剂量给予MBuP后，观察到骨骼畸形胎仔的发生率显著增加。在第7-9天用MBuP处理后主要观察到颈椎畸形。在第13-15天用MBuP治疗后仅发现腭裂和胸骨融合。可以得出结论，MBuP诱导的异常发育表现随给药时的发育阶段而变化。
The objective of this study was to further characterize the developmental toxicity of mono-n-butyl phthalate (MBuP), which is one of the major metabolites of n-butyl benzyl phthalate (BBP) and di-n-butyl phthalate (DBP). Pregnant rats were given MBuP by gastric intubation at a dose of 500, 625 or 750 mg/kg on days 7–9, days 10–12, or days 13–15 of pregnancy. A significantly increased incidence of postimplantation loss was noted in pregnant rats given MBuP on days 7–9 and days 10–12 at doses of 625 mg/kg and above and on days 13–15 at doses of 500 mg/kg and above. No evidence of teratogenicity was found when MBuP was given on days 10–12 of pregnancy. A significantly increased incidence of fetuses with external malformations was found after treatment with MBuP on days 7–9 and days 13–15 at doses of 625 and 750 mg/kg. A significantly increased incidence of fetuses with skeletal malformations was observed after treatment with MBuP on days 7–9 at doses of 500 mg/kg and above and on days 13–15 at doses of 625 mg/kg and above. Deformity of the cervical vertebrae was predominantly observed following treatment with MBuP on days 7–9. Cleft palate and fusion of the sternebrae were exclusively found following treatment with MBuP on days 13–15. It could be concluded that the manifestation of deviant development induced by MBuP varies with the developmental stage at the time of administration.
影响因子：
3.8
作者：
LAMB, JC;CHAPIN, RE;REEL, JR
通讯作者：
REEL, JR