Neurovascular development The beginning of a beautiful friendship
Neurovascular development The beginning of a beautiful friendship
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DOI：
10.4161/cam.3.2.8397
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发表时间：
2009-04-01
影响因子：
3.2
通讯作者：
James, Jennifer M.
中科院分区：
文献类型：
--
作者：
Bautch, Victoria L.;James, Jennifer M.
神经血管在中枢神经系统的发育有着丰富的历史和令人信服的意义。发育中的中枢神经系统(CNS)不产生血管前体细胞，因此血管内陷是中枢神经系统持续发育和功能所必需的。经典研究提供了围绕胚胎大脑和脊髓的血管神经丛的形成，以及随后血管进入神经组织的优雅描述。最近的工作集中在负责神经血管串扰和血脑屏障发展的分子通路上。在这里，我们回顾了中枢神经系统的神经血管发育，重点是脊髓。我们讨论了历史工作、我们的知识现状和尚未回答的问题。讨论了神经血管发育对脑血管疾病和神经干细胞生态位疾病的重要性。
Neurovascular development in the central nervous system has a rich history and compelling significance. The developing central nervous system (CNS) does not produce vascular progenitor cells, and so ingression of blood vessels is required for continued CNS development and function. Classic studies provide elegant descriptions of formation of the vascular plexus that surrounds the embryonic brain and spinal cord, and the subsequent ingression of blood vessels into the neural tissue. Recent work has focused on the molecular pathways responsible for neurovascular cross-talk and development of the blood-brain barrier. Here we review neurovascular development in the central nervous system, with emphasis on the spinal cord. We discuss the historical work, the current status of our knowledge and unanswered questions. The importance of neurovascular development to diseases of the cerebral vasculature and the neural stem cell niche are discussed.