Hg(OTf)2-CatalyzedInstantaneous Hydration of β- and δ-Hydroxy Internal Alkyneswith Complete Regioselectivity
Hg(OTf)2-CatalyzedInstantaneous Hydration of β- and δ-Hydroxy Internal Alkyneswith Complete Regioselectivity
复制标题
Hg(OTf)2 催化 β- 和 δ-羟基内炔的瞬时水合，具有完全区域选择性
作者：
M. Nishizawa*;Takayuki Takemoto;Ikuo Sasaki;Mayo Nakano;Elisabeth Ho;K. Namba;Hirofumi Yamamoto;H. Imagawa
Hg(OTf) 2催化β-和6-羟基内炔的水化反应在温和条件下瞬间发生，生成具有完全区域选择性的酮，而不含羟基部分的内炔的水化反应非常缓慢，生成酮的混合物。如果羟基位于离三键5个以上的碳上，则对水化反应没有显著影响。
The hydration of β- and 6-hydroxy internal alkynes catalyzed by Hg(OTf) 2 took place instantaneously to give ketones with complete regioselectivity under mild conditions, whereas the hydration of internal alkyne without hydroxy moiety was very slow and gave a mixture of ketones. If the hydroxy group is located more than five carbons from the triple bond it has no significant effect upon the hydration reaction.