Distinct [18F]THK5351 binding patterns in primary progressive aphasia variants
Distinct [18F]THK5351 binding patterns in primary progressive aphasia variants
复制标题
原发性进行性失语症变异体中不同的 [18F]THK5351 结合模式
DOI：
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发表时间：
2018
影响因子：
9.1
通讯作者：
R. Vandenberghe
中科院分区：
文献类型：
--
作者：
J. Schaeverbeke;C. Evenepoel;Lieven Declercq;S. Gabel;Karen Meersmans;R. Bruffaerts;Kate Adamczuk;Eva Dries;K. Van Bouwel;A. Sieben;Y. Pijnenburg;R. Peeters;G. Bormans;K. Van Laere;M. Koole;P. Dupont;R. Vandenberghe
目的评估 PET 示踪剂 [18F]THK5351 在不同原发性进行性失语 (PPA) 变异体患者中的结合及其与临床缺陷的相关性。大多数非流利变异 (NFV) 和语言减少变异 (LV) PPA 患者分别患有额颞叶 tau 蛋白病或阿尔茨海默病类型，而语义变异 (SV) 患者主要具有反式反应 DNA 结合蛋白 43-kDa 病理学。 方法该研究包括通过记忆诊所连续招募的 20 名 PPA 患者（12 名 NFV、5 名 SV、3 名 LV）和 20 名健康对照。所有参与者都接受了广泛的神经语言学评估、磁共振成像和淀粉样蛋白生物标志物测试。 [18F]THK5351 结合模式在标准化摄取值比 (SUVR) 图像上进行评估，以小脑灰质作为参考，使用统计参数映射。进行全脑体素回归分析以评估 [18F]THK5351 SUVR 图像与神经语言评分之间的关联。在进行部分体积校正和不进行部分体积校正的情况下进行分析。结果与对照组和 SV 患者相比，NFV 患者的辅助运动区、左前运动皮层、丘脑、基底神经节和中脑的结合增加。与对照组和 NFV 患者相比，SV 患者双侧颞叶和右侧腹内侧额叶皮层的结合增加。全脑体素回归分析揭示了语法错误和运动性言语障碍之间的相关性，以及[18F]THK5351在左侧辅助运动区和左侧中央后回的结合。对未进行部分容积校正的 [18F]THK5351 扫描分析显示了类似的结果。结论 [18F]THK5351 成像显示的地形与 NFV 和 SV PPA 预测的潜在病理特征的解剖分布密切匹配。 [18F]THK5351 结合与临床损伤的严重程度相关。
PurposeTo assess the binding of the PET tracer [18F]THK5351 in patients with different primary progressive aphasia (PPA) variants and its correlation with clinical deficits. The majority of patients with nonfluent variant (NFV) and logopenic variant (LV) PPA have underlying tauopathy of the frontotemporal lobar or Alzheimer disease type, respectively, while patients with the semantic variant (SV) have predominantly transactive response DNA binding protein 43-kDa pathology.MethodsThe study included 20 PPA patients consecutively recruited through a memory clinic (12 NFV, 5 SV, 3 LV), and 20 healthy controls. All participants received an extensive neurolinguistic assessment, magnetic resonance imaging and amyloid biomarker tests. [18F]THK5351 binding patterns were assessed on standardized uptake value ratio (SUVR) images with the cerebellar grey matter as the reference using statistical parametric mapping. Whole-brain voxel-wise regression analysis was performed to evaluate the association between [18F]THK5351 SUVR images and neurolinguistic scores. Analyses were performed with and without partial volume correction.ResultsPatients with NFV showed increased binding in the supplementary motor area, left premotor cortex, thalamus, basal ganglia and midbrain compared with controls and patients with SV. Patients with SV had increased binding in the temporal lobes bilaterally and in the right ventromedial frontal cortex compared with controls and patients with NFV. The whole-brain voxel-wise regression analysis revealed a correlation between agrammatism and motor speech impairment, and [18F]THK5351 binding in the left supplementary motor area and left postcentral gyrus. Analysis of [18F]THK5351 scans without partial volume correction revealed similar results.Conclusion[18F]THK5351 imaging shows a topography closely matching the anatomical distribution of predicted underlying pathology characteristic of NFV and SV PPA. [18F]THK5351 binding correlates with the severity of clinical impairment.
影响因子：
14.5
作者：
Ossenkoppele, Rik;Schonhaut, Daniel R.;Rabinovici, Gil D.
通讯作者：
Rabinovici, Gil D.
影响因子：
14.5
作者：
Josephs, Keith A.;Duffy, Joseph R.;Petersen, Ronald C.
通讯作者：
Petersen, Ronald C.
[18F]AV-1451 体内结合反映了原发性进行性失语症语义变异中 TDP-43 病理学的预期分布
DOI：
10.17863/cam.13435
发表时间：
2018
期刊：
--
影响因子：
--
作者：
Bevan-Jones W
通讯作者：
Bevan-Jones W