Laboratory Diagnosis of Lyme Disease Advances and Challenges
Laboratory Diagnosis of Lyme Disease Advances and Challenges
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DOI：
10.1016/j.idc.2015.02.005
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发表时间：
2015-06-01
影响因子：
4.4
通讯作者：
Marques, Adriana R.
中科院分区：
文献类型：
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作者：
Marques, Adriana R.
大多数用于诊断莱姆病的实验室测试都是基于检测血清中针对伯氏疏螺旋体的抗体反应。基于抗体的测试的敏感性随着感染持续时间的增加而增加。患病早期的患者更有可能得到阴性结果。需要简化莱姆病的检测算法，提高早期疾病的敏感性，同时仍保持高特异性并提供有关感染阶段的信息。活动性感染的即时检测和生物标志物的开发将是该领域的重大进步。
The majority of laboratory tests performed for the diagnosis of Lyme disease are based on detection of the antibody responses against B burgdorferi in serum. The sensitivity of antibody-based tests increases with the duration of the infection. Patients early in their illness are more likely to have a negative result. There is a need to simplify the testing algorithm for Lyme disease, improving sensitivity in early disease while still maintaining high specificity and providing information about the stage of infection. The development of a point of care assay and biomarkers for active infection would be major advances for the field.