New cytotoxic sesterterpenoids and norsesterterpenoids from two sponges of the genus Sarcotragus
New cytotoxic sesterterpenoids and norsesterterpenoids from two sponges of the genus Sarcotragus
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DOI：
10.1021/np030268e
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发表时间：
2003-11-01
影响因子：
5.1
通讯作者：
Jung, JH
中科院分区：
文献类型：
--
作者：
Liu, YH;Mansoor, TA;Jung, JH
从两种Sarcotragus属海绵中分离得到新的去甲甾萜类化合物（3和4）、二甾萜类化合物（6）、吡咯萜类化合物（7-10）和黑海绵素的立体异构体（5），沿着已知的呋喃甾萜类化合物（11-15）。根据NMR和MS分析确定了其总体结构。通过NMR和CD光谱的组合使用来定义立体化学。评价了化合物对五种人肿瘤细胞系的细胞毒性，发现其表现出边缘至中等活性。
New norsesterterpenoids (3 and 4), a sesterterpenoid (6), pyrroloterpenoids (7-10), and a stereoisomer of kurospongin (5) were isolated, along with known furanosesterterpenes (11-15), from two marine sponges of the genus Sarcotragus. The gross structures were established on the basis of NMR and MS analysis. The stereochemistry was defined by combined use of NMR and CD spectroscopy. The compounds were evaluated for cytotoxicity against five human tumor cell lines and were found to exhibit marginal to moderate activity.